86483-53-6 Usage
Uses
Used in Pharmaceutical Industry:
(Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER is used as a drug candidate for its capacity to interact with biological targets, which may lead to the development of new therapeutic agents. Its molecular design suggests that it could be effective in modulating various biological pathways and processes, making it a valuable asset in the search for novel pharmaceuticals.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER serves as a subject of study for understanding its binding affinity, selectivity, and potential mechanisms of action. Researchers may utilize (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER to explore its properties and optimize its structure for specific therapeutic applications.
Used in Drug Design and Development:
(Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER is utilized in the design and development of new drugs, where its unique structural features can be leveraged to create molecules with improved pharmacokinetics, pharmacodynamics, and safety profiles. Its ethyl ester functionality may also facilitate better absorption and metabolism, which are critical factors in drug efficacy and bioavailability.
Check Digit Verification of cas no
The CAS Registry Mumber 86483-53-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,4,8 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 86483-53:
(7*8)+(6*6)+(5*4)+(4*8)+(3*3)+(2*5)+(1*3)=166
166 % 10 = 6
So 86483-53-6 is a valid CAS Registry Number.
86483-53-6Relevant academic research and scientific papers
A norfloxacin, ciprofloxacin and enrofloxacin preparation method
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Paragraph 0061-0062, (2017/04/25)
The invention discloses a preparation method of norfloxacin, ciprofloxacin and enrofloxacin. The preparation method comprises the following steps: directly reacting 1-ethyl-6-fluoro-7-chlo-4-oxo-1,4-dihydro-quinoline-3-carboxylate or 1-cyclopropyl-6-fluoro-7-chlo-4-oxo-1,4-dihydro-quinoline-3-carboxylate with piperazine (or N-ethyl piperazine); and then, performing after-treatment to prepare a corresponding target product norfloxacin (or ciprofloxacin or enrofloxacin). The preparation method disclosed by the invention is short in reaction step, convenient to operate, less investment and beneficial to industrial production; consumption of piperazine (or N-ethyl piperazine) can be reduced by more than half; under the catalytic action, the reaction temperature is low, the byproducts are less, the yield is high and the cost is low; heavy use of inorganic acid and inorganic alkaline is avoided, so that the pollution is reduced.
Cycloaracylation of Enamines, I. - Synthesis of 4-Quinolone-3-carboxylic Acids
Grohe, Klaus,Heitzer, Helmut
, p. 29 - 37 (2007/10/02)
Starting with o-halobenzoyl chlorides 4 and open-chain secondary enamines 5, a new synthesis of 4-quinolone-3-carboxylic acids 12 is described.The reaction of 7-haloquinolone-3-carboxylic acids 12a-k with aliphatic amines 14 produces highly active antibacterial 7-aminoquinolone-3-carboxylic acids 15.The main product of the 1-cyclopropyl series, "ciprofloxacin" (15a), is being developed as a broad-spectrum chemotherapeutic agent.
