367276-83-3Relevant academic research and scientific papers
An unusual stereochemical outcome of radical cyclization: Synthesis of (+)-biotin
Chavan, Subhash P.,Chittiboyina, Amar G.,Ramakrishna, Guduru,Tejwani, Rajkumar B.,Ravindranathan,Kamat, Subhash K.,Rai, Beena,Sivadasan, Latha,Balakrishnan, Kamalam,Ramalingam,Deshpande
, p. 9273 - 9280 (2007/10/03)
An enantioselective synthesis of (+)-biotin 1 starting from naturally available cysteine is described. The key steps are the unusual stereochemical outcome of radical cyclization of compound 10 to prepare 5,5-fused system 11, and the introduction of C4-sidechain at C6 in 13 via a Grignard reaction.
