869093-41-4Relevant academic research and scientific papers
Total synthesis of the hydroxyketone kurasoin A using asymmetric phase-transfer alkylation
Andrus, Merritt B.,Hicken, Erik J.,Stephens, Jeffrey C.,Bedke, D. Karl
, p. 8651 - 8654 (2007/10/03)
The total synthesis of the farnesyltransferase inhibitor kurasoin A has been achieved using a novel asymmetric phase-transfer-catalyzed glycolate alkylation reaction. 2,5-Dimethoxyacetophenone 7 with cinchonidinium catalyst 9 (10 mol %) and hydroxide base
Asymmetric phase-transfer catalyzed glycolate alkylation, investigation of the scope, and application to the synthesis of (-)-ragaglitazar
Andrus, Merritt B.,Hicken, Erik J.,Stephens, Jeffrey C.,Karl Bedke
, p. 9470 - 9479 (2007/10/03)
Asymmetric glycolate alkylation using a protected acetophenone surrogate under solid-liquid phase-transfer conditions is a new approach to the synthesis of 2-hydroxy esters and acids. Diphenylmethyloxy-2,5-dimethoxyacetophenone 1 with a trifluorobenzyl ci
