87202-38-8

Upstream product

• 110-42-9 Methyl decanoate 
• 98-86-2 acetophenone 
• 112-12-9 methyl nonyl ketone 
• 93-89-0 benzoic acid ethyl ester 
• 111-83-1 1-bromo-octane 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 162470-59-9 2-methyl-1-phenyl-1,3-dodecanedione 

Relevant academic research and scientific papers

METHOD FOR SYNTHESIZING BETA-DICARBONYL COMPOUNDS

A method for synthesizing beta-dicarbonyl compounds, particularly beta-diketones, from at least two carbonyl compounds, such as esters and ketones, in the presence of a strong base or a mixture of strong bases by Claisen condensation with a titer of greater than 95%. The method includes providing a synthesis reactor on which a separation column, provided with a condenser and with at least one microwave generator, is mounted; feeding a first carbonyl compound and the strong base into the synthesis reactor; heating the reactor and starting up the condenser; starting up the microwave generator(s); when the mixture is brought to a boil at total flux, feeding the second carbonyl compound into the reactor; and after a waiting time, stopping the reactor and acidifying and washing the reaction mixture.)

Enantioselective borohydride reduction catalyzed by optically active cobalt complexes

The highly enantioselective borohydride reduction of aromatic ketones or imines to the corresponding alcohols was developed in the presence of a catalytic amount of an optically active cobalt(II) complex catalyst. This enantioselective reduction is carried out using a precisely premodified borohydride with alcohols such as tetrahydrofurfuryl alcohol, ethanol and methanol. High optical yields are obtained by choosing the appropriate alcohol as modifiers and a suitable β-ketoiminato ligand of the catalyst. The enantioselective borohydride reduction has been successfully applied to the preparation of optically active 1,3-diols, the stereoselective reduction of diacylferrocenes, and dynamic and/or kinetic resolution of 1,3-dicarbonyl compounds.

Process for the preparation of linear 1,3-diketones

There is disclosed a process for the preparation of 1,3-diketones of formula I STR1 wherein R1 and R2 are each independently of the other C1 -C20 alkyl, phenyl or phenyl which is substituted by halogen, hydroxy, NO2, C1 -C4 alkyl and/or C1 -C4 alkoxy, C7 -C9 phenylalkyl or a radical of formula II wherein A is C1 -C12 alkylene, phenylene or phenylene which is substituted by halogen, hydroxy, NO2, C1 -C4 alkyl and/or C1 -C4 alkoxy, or is C1 -C12 alkylene which is substituted by hydroxy, halogen and/or alkoxy, X is oxygen or sulfur, and R4 is hydrogen, C1 -C18 alkyl, phenyl or phenyl which is substituted by halogen, hydroxy, C1 -C4 alkyl, NO2 and/or C1 -C4 alkoxy, or is C7 -C9 phenylalkyl, and R3 is hydrogen, C1 -C20 alkyl, phenyl or phenyl which is substituted by halogen, hydroxy, C1 -C4 alkyl, NO2 and/or C1 -C4 alkoxy, or is C7 -C9 phenylalkyl. The process comprises carrying out a Claisen condensation of a ketone of formula III STR2 and an ester of formula IV STR3 wherein R5 is C1 -C5 alkyl, phenyl or phenyl which is substituted by halogen, C1 -C4 alkyl or hydroxy, the reaction being carried out with the base used as catalyst, a hydride of an alkali metal or alkaline earth metal or an alcoholate of C1 -C5 alkali metal or C1 -C5 alkaline earth metal, in a mixture of dimethyl sulfoxide and at least one organic solvent which is inert under the reaction conditions.