87538-71-4

Usage

Uses

Used in Pharmaceutical Industry:
(6Z)-6-[2-amino-5-(4-methoxyphenyl)pyrimidin-4(3H)-ylidene]cyclohexa-2,4-dien-1-one is used as a potential pharmaceutical compound for its possible applications in drug development. Its unique structure, which includes a pyrimidine core, a cyclohexa-2,4-dien-1-one moiety, and functional groups like an amino group and a methoxyphenyl group, may contribute to its interaction with biological targets, making it a candidate for further research and development in the pharmaceutical field.
Used in Biological Research:
In the field of biological research, (6Z)-6-[2-amino-5-(4-methoxyphenyl)pyrimidin-4(3H)-ylidene]cyclohexa-2,4-dien-1-one may serve as a valuable compound for studying its interactions with various biological systems. Its structure and composition could provide insights into its potential roles in biological processes, offering opportunities for new discoveries and applications in understanding complex biological mechanisms.

Upstream product

• 4143-74-2 4'-methoxyflavone 
• 124-46-9 guanidine hydrogen carbonate 
• 1621-58-5 3-(4-methoxyphenyl)-4H-chromen-4-one 
• 113-00-8 guanidine nitrate 
• 1776-08-5 (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 118-93-4 o-hydroxyacetophenone 
• 50-01-1 guanidine hydrochloride 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 13400-26-5 3-hydroxychromen-4-one 
• 491-38-3 1-benzopyran-4(4H)-one 
• 34000-29-8 [E]-3-(p-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Pot-economic synthesis of diarylpyrazoles and pyrimidines involving Pd-catalyzed cross-coupling of 3-trifloxychromone and triarylbismuth

Abstract: The present study reveals the formation of 3,4-diarylpyrazole and 4,5-diarylpyrimidine in one-pot operation starting from 3-trifloxychromone and triarylbismuth. The complete process encompasses two steps in the one-pot operation. The first step leads to the formation of isoflavone via cross-coupling reaction of 3-trifloxychromone and triarylbismuth as a threefold arylating reagent. These isoflavones were further converted into 3,4-diarylpyrazole and 4,5-diarylpyrimidine using hydrazine hydrate and guanidinium chloride in the successive step in the same pot. Interestingly the formation of 3,4-diarylpyrazole was achieved in the shortest reaction time i.e., 30 min that too at room temperature. Overall the developed methodology provides easy access to the medicinally important diarylpyrazole and pyrimidine moiety in one-pot operation and in short reaction time. Graphical Abstract: Synopsis The work presented here describes the novel methodology for the formation of medicinally important heterocycles 3,4-diarylpyrazole and 4,5-diarylpyrimidine in one-pot operation starting from 3-trifloxychromone and triarylbismuth.

Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity

A series of novel 2,4,5-substituted pyrimidine derivatives were synthesized and evaluated for inhibition against the human hepatocellular carcinoma BEL-7402 cancer cell line. Several compounds showed potent inhibition with an IC50 value less than 0.10 μM. Structure-activity relationships for this class of compounds at the 2- and 5-position of the pyrimidine scaffold have been elucidated. The most active compound 7gc showed good inhibition of several different human cancer cell lines with IC50 values from 0.024 to 0.55 μM.