87539-07-9

Upstream product

• 1185-02-0 3,4-dimethyl-3,4-hexanediol 
• 151-50-8 potassium cyanide 
• 5296-70-8 methyl 2-ethyl-2-methylbutyrate 
• 75-05-8 acetonitrile 
• 88-09-5 2-Ethylbutanoic acid 
• 816-11-5 2-ethyl-butyric acid methyl ester 
• 2736-40-5 chlorure d'acide ethyl-2 butyrique 
• 7452-79-1 ethyl 2-methylbutyrate 
• 19945-14-3 ethyl α-methyl-α-ethylbutyrate 

Downstream Products

• 19889-37-3 2-methyl-2-ethylbutanoic acid 
• 153308-34-0 3-(1-ethyl-1-methylpropyl)isoxazolin-5-one 

Relevant academic research and scientific papers

A novel synthesis of 3-aryl-5-tert-butyl-4-oxazolin-2-ones

An efficient synthetic method for 3-aryl-5-tert-butyl-4-oxazolin-2-ones (6) is described. The reaction of ethyl N-arylcarbamates (10) with 1-bromo- 3,3-dimethyl-2-butanone (9a) or 1-bromo-3-ethyl-3-methyl-2-pentanone (9b) using 2.2 eq of lithium his(trime

SELECIVE SYNTHESIS OF 3-BULKYALKYLSUBSTITUTED 5-AMINOISOXAZOL

Methyl 2-ethylbutyrate (3) plus lithiumdiisopropylamide reacted with methyl iodide to give methyl 2-ethyl-2-methylbutyrate (4).The methylene carbanion of acetonitrile-generated with lithiumdiisopropylamide- reacted with 4 to give 4-ethyl-4-methyl-3-oxohexanenitrile (5). 3-Ketonitrile 5 reacted with hydroxylamine after 20 min of heating to reflux in ethanol to give 4-ethyl-4-methyl-3-oxoheyanitrile oxime (6).This in aqueous dilute HCl was selectively and quantitatively transformed into 5-amino-3-(1-ethyl-1-methylpropyl)-isoxazol (7).Longer heating of 5 with hydroxylamine directly generated a mixture of 7 with its isomer 3-amino-5-(1-ethyl-1-methylpropyl)isoxazol (7b).Reaction conditions were studied for optimization of the 5-aminoisoxazol 7 synthesis.

Synthesis of 6-t-alkyl-3-pyridazinones

A class of 6-t-alkyl-3-pyridazinones are prepared from 3-t-alkanoyl-2-propenoic acids by irradiation with strong light and reaction with hydrazine.

Synthesis of acetyl-T-alkanes

Acetyl-tertiary-alkanes are prepared by hydrolytic decarboxylation of tertiary-alkanoylacetonitriles with hydrochloric acid.