5296-70-8

Usage

InChI:InChI=1/C8H16O2/c1-5-8(3,6-2)7(9)10-4/h5-6H2,1-4H3

Upstream product

• 60-29-7 diethyl ether 
• 41294-39-7 3-ethyl-1-bromo-pentan-2-one 
• 124-41-4 sodium methylate 
• 556-24-1 methyl 3-methylbutanoate 
• 74-85-1 ethene 
• 868-57-5 methyl 2-methylbutanoate 
• 816-11-5 2-ethyl-butyric acid methyl ester 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 110-54-3 hexane 
• 201230-82-2 carbon monoxide 
• 6137-03-7 3-ethyl-2-pentanone 
• 2736-40-5 chlorure d'acide ethyl-2 butyrique 
• 88-09-5 2-Ethylbutanoic acid 

Downstream Products

• 18371-13-6 2-Methyl-2-ethyl-1-butanol 
• 87539-07-9 4-ethyl-4-methyl-3-oxohexanenitrile 
• 153308-34-0 3-(1-ethyl-1-methylpropyl)isoxazolin-5-one 
• 19889-37-3 2-methyl-2-ethylbutanoic acid 

Relevant academic research and scientific papers

Nickel-catalyzed site-selective alkylation of unactivated C(sp 3)-H bonds

The direct alkylation of unactivated sp3 C-H bonds of aliphatic amides was achieved via nickel catalysis with the assist of a bidentate directing group. The reaction favors the C-H bonds of methyl groups over the methylene C-H bonds and tolerates various functional groups. Moreover, this reaction shows a predominant preference for sp3 C-H bonds of methyl groups via a five-membered ring intermediate over the sp2 C-H bonds of arenes in the cyclometalation step.

Copper-catalyzed site-selective intramolecular amidation of unactivated C(sp3)-H bonds

The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp3 C-H bond functionalization process. The reaction favors predominantly the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds. Moreover, a preference for activating sp3 C-H bonds of β-methyl groups, via a five-membered ring intermediate, over the aromatic sp2 C-H bonds was also observed in the cyclometalation step. Additionally, sp3 C-H bonds of unactivated secondary sp3 C-H bonds could be functionalized by favoring the ring carbon atoms over the linear carbon atoms. Getting ahead on tams: The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp 3 C-H bond functionalization process to deliver β-lactams. The reaction favors the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds, as well as aromatic C(sp2)-H bonds and unactivated secondary C(sp3)-H bonds of rings.

First examples of the selective carbonylation of C6-C10 linear alkanes to tertiary carbonyl-containing compounds

The carbonylation of C6-C10 n-alkanes with CO in the presence of CBr4·2A1Br3 at -40°C and 1 atm CO leads to the products of non-destructive carbonylation, i.e., the esters of tertiary carboxylic acids, R1/

SELECIVE SYNTHESIS OF 3-BULKYALKYLSUBSTITUTED 5-AMINOISOXAZOL

Methyl 2-ethylbutyrate (3) plus lithiumdiisopropylamide reacted with methyl iodide to give methyl 2-ethyl-2-methylbutyrate (4).The methylene carbanion of acetonitrile-generated with lithiumdiisopropylamide- reacted with 4 to give 4-ethyl-4-methyl-3-oxohexanenitrile (5). 3-Ketonitrile 5 reacted with hydroxylamine after 20 min of heating to reflux in ethanol to give 4-ethyl-4-methyl-3-oxoheyanitrile oxime (6).This in aqueous dilute HCl was selectively and quantitatively transformed into 5-amino-3-(1-ethyl-1-methylpropyl)-isoxazol (7).Longer heating of 5 with hydroxylamine directly generated a mixture of 7 with its isomer 3-amino-5-(1-ethyl-1-methylpropyl)isoxazol (7b).Reaction conditions were studied for optimization of the 5-aminoisoxazol 7 synthesis.