879125-58-3

Upstream product

• 7477-66-9 4-oxo-4-(4-bromo-phenyl)-trans-crotonic acid-chloride 
• 124-40-3 dimethyl amine 
• 7647-01-0 hydrogenchloride 
• 878654-34-3 4-oxo-4-(4-bromo-phenyl)-cis-crotonic acid dimethylamide 
• 64-19-7 acetic acid 
• 20972-38-7 (E)-4-(4-bromophenyl)-4-oxobut-2-enoic acid 
• 99-90-1 para-bromoacetophenone 
• 108-86-1 bromobenzene 

Relevant academic research and scientific papers

Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents

A series of novel (E)-4-oxo-2-crotonamide derivatives were designed and synthesized to find potent antituberculosis agents. All the target compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv(MTB). Results reveal that 4-phenyl moiety at part A and short methyl group at part C were found to be favorable. Most of the derivatives displayed promising activity against MTB with MIC ranging from 0.125 to 4 μg/mL. Especially, compound IIIa16 was found to have the best activity with MIC of 0.125 μg/mL against MTB and with MIC in the range of 0.05–0.48 μg/mL against drug-resistant clinical MTB isolates.