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Upstream product

• 45380-51-6 2-methyl-1,3-dioxacyclopentane radical cation 
• 7196-01-2 4-(1-phenylvinyl)morpholine 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 98-86-2 acetophenone 
• 134272-58-5 2-chloroethyl benzoylacetate 
• 107-21-1 ethylene glycol 
• 93-91-4 1-phenylbutan-1,3-dione 
• 128592-71-2 2-(3-oxo-3-phenylpropylidene)-1,3-dioxolane 
• 917-54-4 methyllithium 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Br?nsted acidic cellulose-PO3H: An efficient catalyst for the chemoselective synthesis of fructones and trans-esterification via condensation of acetoacetic esters with alcohols and diols

Cellulose is the most abundant organic source and has expedient a great deal of interest as renewable and emerged as sustainable feedstock. The functionalization of cellulose as designed catalytic system intriguing furnished to the production of fine chemicals. Herein, we synthesized an environmental friendly solid acid catalyst by functionalizing cellulose with phosphoric acid (PO3H). The successful functionalization of cellulose with PO3H was confirmed by 31P NMR, ICP-OES, FE-SEM, and XPS analysis. ICP-OES revealed the presence of phosphorus content of ～1.0 wt. % on the catalyst's surface while elemental mapping by FESEM and XPS shows a uniform distribution of phosphorus over the material. The synthesized solid acid catalyst was utilized for condensation of diols with acetoacetic esters in solvent-free conditions to synthesize fine chemicals. The present approach not only circumvented the one-step protection and other products but more fascinatingly provided trans-esterification of acetoacetic esters with diols and n-alcohols. The catalyst was successfully used for chemoselective protection on ethyl acetoacetate with 1, 2 diols to essential fructone molecule with ～100% conversion and 99% selectivity. The results suggested that the catalyst has the advantage over commercial solid acid heterogeneous and homogeneous catalysts.

1,3-Dioxolanes from carbonyl compounds over zeolite HSZ-360 as a reusable, heterogeneous catalyst

Carbonyl compounds are converted, in good yields, into their 1,3-dioxolanes over zeolite HSZ-360, as a new reusable catalyst. Good chemoselectivity is also observed.

Acylketene acetals in organic synthesis

The preparation and reactivity of achiral and enantiomerically pure acylketene acetals are described. The key reactions of these substrates involve facile conjugate hydroboration and organolithium addition. Enantiomerically pure acylketene acetals were employed to generate a homochiral β-keto ketal through a highly diastereoselective lithium enolate quench. This β-ketal, which was also prepared through a desymmetrization ketalization reaction on a meso dione, was employed in the synthesis of the insect pheromone sitophilure.

Conjugate hydroboration-reduction and organolithium additions to acylketene acetals. Synthesis of monoprotected β-dicarbonyls

Hydride and organolithium additions to acylketene acetals are presented. Results indicate conjugate addition to be the dominant reaction pathway, resulting in the formation of monoprotected β-diketones and β-ketoaldehydes.

Oxidative Carbon-Carbon Bond Forming Reaction via a 1,3-Dioxolan-2-ylium Cation

1,3-Dioxolan-2-ylium cations, derived from aldehyde ethylene acetals and trityl cation, react with ketene silyl acetals and enamines to give the corresponding β-keto esters and 1,3-diketones, respectively.