88641-61-6

Upstream product

• 592-84-7 n-butyl formate 
• 201230-82-2 carbon monoxide 
• 100-42-5 styrene 
• 71-36-3 butan-1-ol 
• 492-37-5 hydratropic acid 
• 98-85-1 1-Phenylethanol 
• 219951-25-4 (+/-)-pentafluorophenyl 2-phenylpropionate 
• 67-56-1 methanol 
• 592-76-7 1-Heptene 
• 67863-40-5 lithium isopropenolate 
• 3156-07-8 methyl phenyl ketene 
• 109-72-8 n-butyllithium 

Downstream Products

• 1018075-28-9 2-(3-chlorosulfonyl-phenyl)propionic butyl ester 
• 1018075-21-2 2-(4-chlorosulfonyl-phenyl)propionic butyl ester 

Relevant academic research and scientific papers

Xylella fastidiosa esterase rather than hydroxynitrile lyase

In 2009, we reported that the product of the gene SCJ21.16 (XFa0032) from Xylella fastidiosa, a xylem-restricted plant pathogen that causes a range of diseases in several important crops, encodes a protein (XfHNL) with putative hydroxynitrile lyase activi

Hydroesterification of styrene derivatives catalyzed by an acidic resin supporting palladium complexes

Pd-TPPTS-OTPPTS (denoted as Pd-P-OP, where TPPTS was the sodium salt of tri(m-sulfophenyl)phosphine and OTPPTS was the oxidized form of TPPTS) complexes supported on acidic resins (denoted as Pd-P-OP/resin) were prepared and employed as versatile heterogeneous catalysts for the hydroesterification of vinyl-aromatics with alcohols. The catalysts were characterized by the methods of FT-IR, XPS, N2 physisorption, XRD, TGA, SEM and 31P NMR. According to the 31P NMR results, there was a weak coordination between OTPPTS and the Pd sites. Consequently, OTPPTS was a weak ligand to the Pd sites and thus dissociated easily, acting as a protective agent of the vacant coordination site of the Pd metal sites, which allowed the substrates more access to the metal sites. In the hydroesterification of styrene, the distribution of the branched and linear esters was remarkably impacted by adding an appropriate amount of OTPPTS and the acidic resin supports. A high yield and excellent selectivity towards the branched ester were obtained when OTPPTS and TPPTS were used in equimolar amounts under optimized reaction conditions. The generality and recyclability of the catalyst for the hydroesterification of vinyl-aromatics were also examined. In addition, the poisoning and hot filtration tests indicated that Pd(0) acted as the active species in a truly heterogeneous way. A Pd-hydride mechanism was proposed for the hydroesterification over the Pd-P-OP/LSI-600 catalyst. This journal is the Partner Organisations 2014.

Disulfide symmetric dimers as stable pre-hapten forms for bioconjugation: A strategy to prepare immunoreagents for the detection of sulfophenyl carboxylate residues in environmental samples

A convenient, generic synthesis of bioconjugates from haptens with a thiol group has been established. The corresponding haptens are synthesized as stable symmetric dimmers through a disulfide bond that is reduced immediately before conjugation with the a

Parallel kinetic resolution of 1-phenylethanol using quasi-enantiomeric active esters

The parallel kinetic resolution of racemic 1-phenylethanol using an equimolar combination of quasi-enantiomeric pentafluorophenyl esters is discussed. The levels of diastereoselectivity were excellent (>88% de) leading to separable quasi-enantiomeric esters in good yields. Georg Thieme Verlag Stuttgart.

Kinetics and mechanism of styrene hydrocarboalkoxylation catalyzed by Pd° complex in the presence of toluenesulfonic acid

The kinetics of the catalytic reaction of styrene with CO and n-butanol in the Pd(dba)2 - TsOH - Ph3P system in dioxane (383 K) was studied. The initial rates of accumulation of regioisomeric products (butyl 2-and 3-phenylpropionates) were measured as functions of the CO pressure, reactant concentrations, and the catalytic system components. A kinetic model of the process and a hydride mechanism with the HPd(Ph3P)3+ cationic complex acting as a key intermediate were proposed.

Hydrocarbalkoxylation of styrene, catalyzed by a palladium complex of dibenzylideneacetone in the presence of Broensted Acids

The effect of the composition of the catalytic system Pd(dba)2/n HX/8 Ph3P (dba is dibenzylideneacetone) on the yield and ratio of the regioisomeric products of the reaction of styrene with CO and BuOH in dioxane was studied. In comparable conditions, the catalytic activity varies in the order: X = ClO4 ≥ CF3SO3?TsO?Cl ? BF4 ? CF3COO. At X = ClO4, TsO, and CF3SO3, increase in the selectivity of the process in butyl 3-phenylpropanoate is observed at the same or increased catalytic activity. The varied selectivity of the catalytic systems is explained in terms of formation of cationic palladium hydride intermediates. 2000 MAIK "Nauka/Interperiodica".

Effect of Cobalt Chloride on the Regioselectivity of Reaction of Olefins with Carbon Monoxide and Alcohols, Catalyzed with PdCl2(Ph3P)2

Cobalt(II) chloride additives increase the regioselectivity of reaction of 1-heptene and styrene with CO in the presence of methanol and n-butanol, catalyzed by PdCl2(Ph3P)2, toward formation of linear esters, with simultaneous increase in the total product yield. The effect of CoCl2 is the most pronounced in hydrocarboalkoxylation of styrene in dioxane: in the presence of the promoter the isomeric composition of the reaction product becomes inverse. The causes of such an effect of CoCl2 are discussed in terms of formation of Co(I) complexes under reaction conditions.

Nucleophilic Additions to Ketenes by (Trimethylsilyl)lithium and by Enolates

Reaction of t-Bu2C=C=O (5) with Me3SiLi at -78 deg C followed by trapping of the intermediate enolate with Ac2O gave t-Bu2C=C(OAc)SiMe3 (9).Other ketenes gave similar products.Reaction of ketenes PhCR=C=O (R = Me, 13; R = Et, 3) with enolates CH2=C(OLi)R1 (R1 = H, Me, t-Bu, Ph) at -78 deg C followed by warming to 25 deg C and hydrolysis gave vinyl esters PhCHRCO2C(R1)=CH2, along with 10 percent PhCHMeCOCH2COPh for R = Me, R1 = Ph.Under the same conditions the ketenes PhCR=C=O with enolates CH2=C(OK)R1 (R1 = Me, t-Bu, Ph) gave only 1,3-diketones PhCHRCOCH2COR1, but vinyl esters were the major products if the reactions were quenched at -78 deg C.It is proposed that enolates undergo preferential O-acylation by ketenes in a kinetically favored process, but that these intermediates can revert to thermodynamically more stable C-acylated products.

Mono- and Bi-metallic Catalysed Formate-Halide Carbonylation Reactions

Benzylic, aryl, and alkyl halides react with formate esters and carbon monoxide, in the presence of the dimer of chloro(hexa-1,5-diene)rhodium(I), 2, to give carboxylic esters: bimetallic catalysis 2> is particularly beneficial when an aromatic halide is used as the substrate.