88730-41-0

Basic information

• Product Name: Acetamide, N-(3-chlorophenyl)-N-hydroxy-
• CAS NO: 88730-41-0
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Mol File: 88730-41-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(3-chlorophenyl)-N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(3-chlorophenyl)-N-hydroxy-(88730-41-0)
• EPA Substance Registry System: Acetamide, N-(3-chlorophenyl)-N-hydroxy-(88730-41-0)

Safety Data

• Hazardous Substances Data: 88730-41-0(Hazardous Substances Data)

Upstream product

• 932-78-5 1-chloro-3-nitrosobenzene 
• 431-03-8 dimethylglyoxal 
• 113-24-6 sodium pyruvate 
• 108-42-9 3-chloro-aniline 
• 121-73-3 3-Nitrochlorobenzene 
• 10468-17-4 N-(3-chlorophenyl)hydroxylamine 
• 75-36-5 acetyl chloride 
• 127-17-3 2-oxo-propionic acid 

Downstream Products

• 151057-48-6 methyl (E)-3-(2-acetamido-4-chlorophenyl)acrylate 
• 88730-34-1 C₉H₁₀ClNO₄S 

Relevant articles and documents

Transketolase Catalyzed Synthesis of N-Aryl Hydroxamic Acids

Hydroxamic acids are metal-chelating compounds that show important biological activity including anti-tumor effects. We have recently engineered the transketolase from Geobacillus stearothermopilus (TKgst) to convert benzaldehyde as a non-natur

Rhodium(III)-catalyzed internal oxidative coupling of N-hydroxyanilides with alkenes via C-H activation

Abstract Described herein is an efficient new method for ortho-olefination of anilides in the presence of AgSbF6 and NaOAc via rhodium(III)-catalyzed internal oxidative C-H bond activation based on hydroxyl as directing and oxidative group. A range of alkenes and functional groups on acetanilides is supported and a possible mechanism is proposed according to the experimental results.

N-Arylhydroxamic Acids: Reaction of Nitroso Aromatics with α-Oxo Acids

A practical and high-yielding route to N-arylhydroxamic acids from nitroso aromatics and α-oxo acids 1a-d is desctibed.In aqueous and acetic acid containing media, the reactions exhibit second-order reaction kinetics overall.In the aqueous medium, the rate constant (kobsd) for N-phenylacetohydroxamic acid (8b) formation increased with increasing +>, though there were some side pathways involving azoxybenzene formation.In general, kobsd for the reaction in the acetic acid containing medium was about one-tenth of that in HCl at pH 0.6.On a preparative scale, acetic acid is better than HCl, in that both reactants showed sufficient solubilities in acetic acid for a high reaction velocity and no side reaction was detected.With this method, the proximate carcinogens, N-(4-biphenylyl)acetohydroxamic acid (12b) and N-(2-fluorenyl)acetohydroxamic acid (13b), could be easily prepared.Under both conditions, the order of kobsd for the reactions of nitrosobenzene (2) with α-oxo acids 1a-d was glyoxylic (1a) > pyruvic (1b) 2-oxobutyric (1c) > benzoylformic (1d) acid.For the reactions of substituted nitrosobenzenes 3-6 with pyruvic acid (1b), the order of kobsd was p-phenyl (6) > unsubstituted (2) > p-chloro (5) > m-chloro (4) >> o-chloro (3) nitrosobenzene.The negative Hammett reaction constant value obtained indicates that an electron-donating substituent is preferable for the reaction.The reaction mechanism and other factors affecting N-arylhydroxamic acid formation are also descussed.