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Upstream product

• 95-21-6 2-methyl-1,3-benzoxazole 
• 100-52-7 benzaldehyde 
• 54638-91-4 2-(3-phenyl-2-propyleneamino)-phenol 
• 614-80-2 2-(acetylamino)phenol 
• 621-82-9 Cinnamic acid 
• 95-55-6 2-amino-phenol 
• 104-55-2 3-phenyl-propenal 
• 104-54-1 3-Phenylpropenol 
• 88-75-5 2-hydroxynitrobenzene 
• 102-92-1 cinnamoyl chloride 
• 615-36-1 2-bromoaniline 
• 23785-53-7 N-(2-hydroxyphenyl)cinnamoyl amide 
• 102-92-1 Cinnamoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 

Downstream Products

• 83318-25-6 2-(β-phenylethyl)benzoxazole 
• 85678-52-0 4-Benzooxazol-2-yl-1,2,3-triphenyl-butan-1-one 
• 85678-61-1 C₂₉H₂₂N₂O₂ 
• 344754-00-3 2-(3-Benzothiazol-2-yl-2,3-diphenyl-propyl)-benzooxazole 
• 100742-71-0 4-Benzooxazol-2-yl-2,3-diphenyl-butyric acid tert-butyl ester 
• 85678-54-2 4-Benzooxazol-2-yl-2,3-diphenyl-butyronitrile 
• 85678-66-6 2-(2,4,5-Triphenyl-pyrrolidin-3-yl)-benzooxazole 
• 85678-53-1 5-Benzooxazol-2-yl-3,4-diphenyl-pentan-2-one 
• 345942-89-4 4-Benzooxazol-2-yl-2,3-diphenyl-butyric acid methyl ester 
• 85678-64-4 4-Benzooxazol-2-yl-2,3-diphenyl-butyric acid 
• 1252606-10-2 2-[(R)-2-naphthalen-2-yl-2-phenylethyl]benzooxazole 
• 1572040-09-5 (3R)-N-(2-hydroxyphenyl)-3-(4-methylphenyl)-3-phenylpropanamide 
• 1572039-89-4 2-[(R)-2-(4-methylphenyl)-2-phenylethyl]benzooxazole 

Relevant academic research and scientific papers

Dowex 50W: A green mild reusable catalyst for the synthesis of 2-aryl benzoxazole derivatives in aqueous medium

In this work simple efficient, one pot and environmentally friendly method was developed for the synthesis of 2-Aryl-1H-benzoxazole derivatives at 80oC using ortho-aminophenol and various aldehydes. It has been found that Dowex 50W is an effective catalyst to prepare moderate to high yield of a variety of benzoxazole derivatives through a clean and simple process. Aqueous medium, green methodology, rapid reaction, reusability of heterogeneous catalyst are the great advantages of this protocol.

Iron(0)-Catalyzed Transfer Hydrogenative Condensation of Nitroarenes with Alcohols: A Straightforward Approach to Benzoxazoles, Benzothiazoles, and Benzimidazoles

The iron-catalyzed hydrogen transfer strategy has been applied to the redox condensation of o-hydroxynitrobenzene with alcohol, leading to the formation of benzoxazole derivatives. A wide range of 2-substituted benzoxazoles were synthesized in good to excellent yields without the addition of an external redox agent. A series of control experiments provided a plausible mechanism. Furthermore, the reaction system was successfully extended to the synthesis of benzothiazoles and benzimidazoles.

Hemoglobin: A New Biocatalyst for the Synthesis of 2-substituted Benzoxazoles via Oxidative Cyclization

Efficient and mild synthesis of a series of 2-substituted benzoxazoles via oxidative cyclization catalyzed by hemoglobins reported here for the first time. Satisfactory yields (84 %–97 %) and mild reaction conditions make this method highly viable for practical applications.

A by bio-catalytic oxidation cyclized synthesis of 2 - substituted benzoxazole compound green method (by machine translation)

The invention discloses a by bio-catalytic oxidation cyclized synthesis of 2 - substituted benzoxazole compound green method, which belongs to the technical field of biological catalytic synthesis, uses aldehyde and phenol amine or benzoxazole and cyclic secondary amine as the substrate of reaction, methylene chloride as the solvent, biological protein as a catalyst. Operation comprises the following steps first reaction to produce intermediate of the reaction substrate, then the hemoglobin, the oxidizing agent, the solvent is added in a reaction vessel, the reaction at room temperature under the condition of 2 hours. The experiment shows that, various types of hemoglobin and horse radish peroxidase and heme to said reaction have a catalytic effect, wherein the Vitreoscilla hemoglobin catalytic effect is the best, yield is up to 91%, superior to the traditional chemical synthesis method. The use of hemoglobin catalysts such as than the traditional chemical synthesis method more green environmental protection, is characterized in that: there are no harmful reagent to use, may be any metal ion catalysis, reduce the amount of the oxidizing agent and the catalyst. (by machine translation)

Ligand-promoted, copper nanoparticles catalyzed one-pot synthesis of substituted benzoxazoles from 2-bromoanilines and acyl chlorides

A facile, highly efficient, and practical one-pot synthetic strategy for benzoxazoles was developed by using copper nanoparticles as a catalyst with o-bromoanilines and acyl chlorides as starting materials. With the promotion of 1,10-phenanthroline ligand, the copper nanoparticles catalyst showed highly catalytic activity under mild conditions. This methodology is tolerant of a wide variety of functional groups and gives good to excellent yields in most examples. Furthermore, the solid catalyst could be recovered and reused conveniently several times with satisfactory yields.

Nano ceria catalyzed synthesis of substituted benzimidazole, benzothiazole, and benzoxazole in aqueous media

A series of substituted benzimidazoles, benzothiazoles, and benzoxazoles was synthesized by combining 1,2-phenylenediamine, 2-aminothiophenol, or 2-aminophenol with aryl, heteroaryl, aliphatic, α,β-unsaturated aldehydes in the presence of nano ceria (CeO2) as an efficient heterogeneous catalyst.

An efficient synthesis of 2-substituted benzoxazoles using cerium(III) chloride/sodium iodide as catalyst

An efficient and environmentally benign method for the synthesis of 2-substituted benzoxazoles is reported. The condensation of 2-aminophenol with an aldehyde gave an imine intermediate, which was cyclized and dehydrogenated to 2-substituted benzoxazole with good yield in the presence of CeCl 3 /NaI as catalyst. The one-pot synthesis was carried out in toluene at 100 ° C using O 2 as the oxidant.

Efficient protocol for the synthesis of quinoxaline, benzoxazole and benzimidazole derivatives using glycerol as green solvent

A straightforward, efficient and more sustainable catalyst-free method has been developed for the synthesis of quinoxaline, benzoxazole, and benzimidazole ring system in glycerol to achieve yields that were comparable to or better than, those in conventional media. It is noteworthy that the reaction was exclusively carried out in glycerol-water system, rendering the methodology highly valuable from both environment and economic points of view.

A convenient synthesis of 2-oxazolines and 2-benoxazoles with PPh3-DDQ as the dehydrating reagent

2-Oxazolines and 2-benoxazoles were synthesized in high yields from acylamino alcohols and acylaminophenols, respectively, with triphenylphosphine- 2,3-dichloro-5,6-dicyanobenzoquinone (PPh3-DDQ) as the dehydrating and activating reagent. The synthesis was accomplished under neutral conditions.

Lawesson's reagent and microwaves: A new efficient access to benzoxazoles and benzothiazoles from carboxylic acids under solvent-free conditions

Lawesson's reagent acts as an efficient promoter in the solvent-free microwave-assisted synthesis of 2-substituted benzoxazoles from carboxylic acids and 2-aminophenol, and thus, constitutes a general synthetic method for these compounds. This new application of Lawesson's reagent is valid also for benzothiazoles with very high efficiency level. A variety of aromatic, heteroaromatic and aliphatic carboxylic acids react under the conditions developed with good yields in all cases. Thiobenzoic acid is a good alternative for microwave-assisted synthesis of 2-phenylbenzoxazole and 2- phenylbenzothiazole in the absence of solvents. Georg Thieme Verlag Stuttgart.