89193-18-0Relevant academic research and scientific papers
WNT SIGNALING PATHWAY INHIBITORS FOR TREATMENTS OF DISEASE
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Paragraph 00277; 00278, (2017/09/15)
Compounds and compositions are provided as inhibitors of the Wnt/β-catenin pathway for the treatment of diseases that implicate the same.
PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES
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Paragraph 0162-0166, (2013/03/26)
The invention describes a novel process for synthesizing pyrazoles by means of oxidative conversion of enamines with suitable N-containing carboxylic acid derivatives.
Synthesis of a pyrazol-3-ylidene palladium complex, pyrazolium salts and mesomeric betaines of pyrazole as N-heterocyclic carbene precursors
Dreger, Andrij,Nieger, Martin,Drafz, Martin,Schmidt, Andreas
experimental part, p. 359 - 366 (2012/07/14)
The synthesis of a pyrazol-3-ylidene palladium complex is described, and results of a single-crystal X-ray diffraction study are presented. The properties of pyrazolium salts as well as of two types of heterocyclic mesomeric betaines, the pseudo-cross-con
Efficient synthesis of pyrazoles: Oxidative C-C/N-N bond-formation cascade
Neumann, Julia J.,Suri, Mamta,Glorius, Frank
supporting information; experimental part, p. 7790 - 7794 (2011/01/09)
Golden section: A novel synthetic strategy for the synthesis of tetrasubstituted pyrazoles is provided. In an efficient C-C/N-N bond-formation cascade, enamines and nitriles are oxidatively coupled to deliver pyrazoles in good yields (see scheme). The rea
An effective and general method for the highly regioselective synthesis of 1-phenylpyrazoles from β-enaminoketoesters, tandem Blaise-acylation adducts
Ko, Young Ok,Chun, Yu Sung,Park, Cho-Long,Kim, Youngmee,Shin, Hyunik,Ahn, Sungho,Hong, Jongki,Lee, Sang-Gi
supporting information; experimental part, p. 1132 - 1136 (2009/05/30)
An effective and general route for the regioselective synthesis of 1-phenylpyrazoles has been developed from β-enaminoketoesters prepared by tandem Blaise-acylation. This method is applicable to a very broad range of substrates, generating a diverse set o
Cyclic AMP-specific phosphodiesterase inhibitors
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, (2008/06/13)
Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as
Study of the reaction of 2-acyl 1,3-dicarbonyl compounds with hydrazines by 1H NMR spectroscopy
Emelina, E. E.,Ershov, B. A.,Zelenin, A. K.,Selivanov, S. I.
, p. 1630 - 1636 (2007/10/03)
The reaction of 2-acyl 1,3-dicarbonyl compounds with hydrazine and phenylhydrazine was studied by 1H NMR spectroscopy.It was shown that the formation of functionally 4-substituted pyrazoles is promoted if the reaction is conducted in protic solvents at reduced temperature.The presence of the benzoyl groups in the 2-acyl 1,3-dicarbonyl compounds leads to the preferential formation of the cleavage products, i.e., the corresponding acylhydrazines and 1,3-dicarbonyl compounds.It was established that the initial reaction product is consumed in two directions, i.e., cyclization with the formation of functionally 4-substituted pyyrazoles and cleavage with the formation of acetylhydrazines and the corresponding 1,3-dicarbonyl compounds.
Reaction of 2-(1-alkoxyethylidene) 1,3-dicarbonyl compounds with nitrogen-containing binucleophiles
Emelina, E. E.,Ermakov, N. V.,Ershov, B. A.,Zelenin, A. K.
, p. 1637 - 1639 (2007/10/03)
The reaction of 2-(1-alkoxyethylidene) 1,3-dicarbonyl compounds with hydrazine, phenylhydrazine, urea, and dimethylhydrazine leads to high yields of the corresponding functionally substituted pyrazoles, pyrimidines, and enehydrazines.
