91349-11-0

Usage

Uses

Used in Pharmaceutical Development:
1-(4-chlorobenzyl)pyrrolidine-2,5-dione is used as a building block for the development of new pharmaceuticals due to its potential biological activity and the presence of a 4-chlorobenzyl group, which is often found in various drugs.
Used in Agrochemicals:
1-(4-chlorobenzyl)pyrrolidine-2,5-dione is used as a starting material or intermediate in the synthesis of agrochemicals, taking advantage of its chemical structure and potential reactivity.
Used in Materials Science:
1-(4-chlorobenzyl)pyrrolidine-2,5-dione may be utilized in the development of new materials, potentially due to its unique chemical structure and properties that could be exploited in material applications.
Used in Organic Synthesis:
1-(4-chlorobenzyl)pyrrolidine-2,5-dione serves as a key intermediate in organic synthesis, where its specific functional groups can be further modified to produce a variety of target compounds for different applications.
(Note: The uses listed are speculative based on the general properties of similar compounds and would need to be confirmed through experimental research and development.)

Upstream product

• 108-30-5 succinic acid anhydride 
• 104-86-9 4-chlorobenzylamine 
• 623-03-0 4-Cyanochlorobenzene 
• 110-63-4 Butane-1,4-diol 
• 128-08-5 N-Bromosuccinimide 
• 106-43-4 para-chlorotoluene 

Relevant academic research and scientific papers

Preparation method of N-(aryl/heteroaryl) alkyl-diamide

The invention relates to a preparation method of N-(aryl/heteroaryl)alkyl- diamide, which comprises the following steps: under the protection of nitrogen, sequentially adding transition metal, phosphine or nitrogen ligand, cocatalyst, alkali, solvent, Nhalogenated cyclodiamide, alkyl aromatic ring or alkyl heteroaromatic ring compound into a reaction container, carrying out oxidative amination reaction at 80-140 DEG C, and till the reaction concludes after 6-48 hours, evaporating and drying a solvent and carrying out column chromatography separation to obtain an N (aryl/heteroaryl) alkyl diamide compound. The invention is simple in synthesis process, mild in reaction condition, high in yield and easy to industrialize.

Synthesis of Cyclic Imides by Acceptorless Dehydrogenative Coupling of Diols and Amines Catalyzed by a Manganese Pincer Complex

The first example of base-metal-catalyzed dehydrogenative coupling of diols and amines to form cyclic imides is reported. The reaction is catalyzed by a pincer complex of the earth abundant manganese and forms hydrogen gas as the sole byproduct, making the overall process atom economical and environmentally benign.

Direct Synthesis of Cyclic Imides from Carboxylic Anhydrides and Amines by Nb2O5 as a Water-Tolerant Lewis Acid Catalyst

In the 20 types of heterogeneous and homogenous catalysts screened, Nb2O5 showed the highest activity for the synthesis of N-phenylsuccinimide by dehydrative condensation of succinic anhydride and aniline. Nb2O5 was used in the direct imidation of a wide range of carboxylic anhydrides with NH3 or amines with various functional groups and could be reused. Kinetic studies showed that the Lewis acid Nb2O5 catalyst was more water tolerant than both the Lewis acidic oxide TiO2 and the homogeneous Lewis acid ZrCl4, which resulted in higher yields of imides through the use of Nb2O5. Int-imidation tactics: A general method for the direct synthesis of cyclic imides from cyclic anhydrides with amines (or ammonia) under solvent-free conditions is reported. Kinetic studies indicate that the Lewis acid sites of Nb2O5 are highly water tolerant, which results in high catalytic activity for imidation even in the presence of water formed during the reaction. The catalyst can be recovered and reused four times without a marked decrease in yield.

Synthesis of cyclic imides from nitriles and diols using hydrogen transfer as a substrate-activating strategy

An atom-economical and versatile method for the synthesis of cyclic imides from nitriles and diols was developed. The method utilizes a Ru-catalyzed transfer-hydrogenation reaction in which the substrates, diols, and nitriles are simultaneously activated into lactones and amines in a redox-neutral manner to afford the corresponding cyclic imides with evolution of H2 gas as the sole byproduct. This operationally simple and catalytic synthetic method provides a sustainable and easily accessible route to cyclic imides.

Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase

Human immunodeficiency virus type-1 integrase is an essential enzyme for effective viral replication and hence a valid target for the design of inhibitors. We report here on the design and synthesis of a novel series of phthalimide analogues as integrase