914942-87-3Relevant articles and documents
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IκB kinase
Kempson, James,Guo, Junqing,Das, Jagabandhu,Moquin, Robert V.,Spergel, Steven H.,Watterson, Scott H.,Langevine, Charles M.,Dyckman, Alaric J.,Pattoli, Mark,Burke, James R.,Yang, XiaoXia,Gillooly, Kathleen M.,McIntyre, Kim W.,Chen, Laishun,Dodd, John H.,McKinnon, Murray,Barrish, Joel C.,Pitts, William J.
scheme or table, p. 2646 - 2649 (2009/12/31)
A new series of tricyclic-based inhibitors of IKK have been derived from an earlier lead compound. The synthesis and structure-activity relationships (SAR) are described. Compound 4k inhibited TNF production in rats stimulated with LPS.