887147-21-9

Upstream product

• 887147-19-5 4,6-dichloro-1-methyl-1H-imidazo [4,5-c]pyridine 
• 74-89-5 methylamine 
• 26820-38-2 (3,5-dinitropyridin-4-yl)methylamine 
• 10425-70-4 4-chloro-3,5-dinitropyridine 
• 19872-96-9 1H-3,5-dinitropyridine-4-one 
• 914942-86-2 2,6-dichloro-4-N-methylpyridine-3,4-diamine 
• 914942-85-1 2,6-dichloro-N-methyl-N-nitro pyridine-4-amine 
• 887147-20-8 2,6-dichloro-N-methyl-3-nitro pyridine-4-amine 
• 175461-33-3 2,6-dichloro-N-methylpyridine-4-amine 
• 805316-71-6 2,6-dichloro-N'-methylpyridine-3,4,5-triamine 
• 805316-72-7 7-amino-4,6-dichloro-1-methyl-1H-imidazo[4,5-c]pyridine 
• 16063-69-7 2,4,6-trichloropyridine 
• 626-64-2 pyridin-4-ol 

Downstream Products

• 914942-88-4 tert-butyl (6-amino-7-iodo-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl)(methyl)carbamate 
• 914942-90-8 tert-butyl methyl(1-methyl-7-phenyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-yl)carbamate 
• 914942-89-5 tert-butyl 6-amino-1-methyl-7-(2-phenylethynyl)-1H-imidazo[4,5-c]pyridin-4-yl(methyl)carbamate 
• 914942-87-3 tert-butyl 6-(diphenylmethyleneamino)-1-methyl-1H-imidazo[4,5-c]pyridine-4-yl(methyl)carbamate 
• 914944-39-1 N-[[4-[1,6-dihydro-1-methyl-4-(methylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]phenyl]methyl]-acetamide 
• 914943-96-7 7-(3-bromophenyl)-1,6-dihydro-N,1-dimethyl-1-(tert-butyloxycarbonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine 
• 914942-93-1 3-[1,6-dihydro-1-methyl-4-(N-tert-butyloxycarbonyl-N-methylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]benzonitrile 
• 914944-38-0 4-[1,5-dihydro-1-methyl-4-(N-tert-butyloxycarbonyl-N-methylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]benzonitrile 
• 914942-96-4 7-[3-(aminomethyl)phenyl]-1,6-dihydro-N,1-dimethyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-(t-butyloxycarbonylamine) 
• 914944-36-8 7-[4-(aminomethyl)phenyl]-1,5-dihydro-N,1-dimethyl-imidazo[4,5-c]pyrrolo[2,3-b]pyridin-4-(t-butyloxycarbonylamine) 

Relevant academic research and scientific papers

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IκB kinase

A new series of tricyclic-based inhibitors of IKK have been derived from an earlier lead compound. The synthesis and structure-activity relationships (SAR) are described. Compound 4k inhibited TNF production in rats stimulated with LPS.

8H-IMIDAZO[4,5-D]THIAZOLO[4,5-B]PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I) wherein R1, R2, R5 and R6 are as described herein. The present invention further provides pharmaceutical compo

1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY

The present invention provides for tricyclic compounds having the formula (I) wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.