915140-96-4

Usage

Uses

Used in Pharmaceutical Industry:
6-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid is used as a key intermediate in the synthesis of pharmaceutical compounds for its structural diversity and potential pharmacological applications. It contributes to the development of new drugs targeting a range of diseases, including cancer and neurodegenerative disorders.
Used in Agrochemical Industry:
6-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid is utilized as a building block in the synthesis of agrochemicals, particularly for the development of novel pesticides and herbicides. Its unique structure and properties allow for the creation of effective and targeted agrochemicals to improve crop protection and yield.
Used in Medicinal Chemistry Research:
6-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid is employed as a valuable research tool in medicinal chemistry, enabling the exploration of its therapeutic properties and potential applications in drug development. Its structural features and biological activity make it a promising candidate for the discovery of new therapeutic agents and the advancement of medicinal chemistry knowledge.

InChI:InChI=1/C9H7ClN2O2/c10-7-2-1-6-5(3-8(13)14)4-11-9(6)12-7/h1-2,4H,3H2,(H,11,12)(H,13,14)

Upstream product

• 1296201-71-2 C₁₅H₂₁ClN₂OSi 
• 45644-21-1 6-chloropyridin-2-amine 
• 800402-05-5 N-(6-chloro-3-iodopyridin-2-yl)-tert-butylamide 
• 86847-84-9 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide 
• 55052-27-2 6-chloro-7-azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 1350725-40-4 C₉H₄ClF₃N₂O 
• 849068-50-4 ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 
• 271-63-6 7-Azaindole 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 1296203-11-6 C₁₆H₁₄ClN₃O₂ 

Relevant academic research and scientific papers

BICYCLIC HETEROARYLS AS KINASE INHIBITORS

The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Rho kinase (ROCK) inhibitors are potential therapeutic agents to treat disorders such as hypertension, multiple sclerosis, cancers, and glaucoma. Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC 50 = 1 nM) with 740-fold selectivity over PKA (47). Moreover, 47 showed very good DMPK properties making it a good candidate for further development. Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.

Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof

This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising

1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof

The present invention discloses and claims compounds of general formula in which X represents a nitrogen atom or a group of formula C—R2, P represents a group of formula C—R3, Q represents a group of formula C—R4, R represents a group of formula C—R5, W represents a group of formula C—R6, or one of the symbols P, Q, R and W represents a nitrogen atom, R1 represents a hydrogen atom or an alkyl group, R2 represents a hydrogen atom or an alkyl group, R3, R4, R5 and R6 each represent a hydrogen or halogen atom, or an alkyl, alkoxy, nitro, amino, trifluoromethyl, cyano or amino group or other functional groups. The compounds of the invention are useful in a variety of therapeutic applications.