91901-31-4Relevant academic research and scientific papers
Dimsyl Anion Enables Visible-Light-Promoted Charge Transfer in Cross-Coupling Reactions of Aryl Halides
Pan, Lei,Cooke, Maria Victoria,Spencer, Amara,Laulhé, Sébastien
supporting information, p. 420 - 425 (2021/11/01)
A methodology is reported for visible-light-promoted synthesis of unsymmetrical chalcogenides enabled by dimsyl anion in the absence of transition-metals or photoredox catalysts. The cross-coupling reaction between aryl halides and diaryl dichalcogenides proceeds with electron-rich, electron-poor, and heteroaromatic moieties. Mechanistic investigations using UV-Vis spectroscopy, time-dependent density functional theory (TD-DFT) calculations, and control reactions suggest that dimsyl anion forms an electron-donor-acceptor (EDA) complex capable of absorbing blue light, leading to a charge transfer responsible for generation of aryl radicals from aryl halides. This previously unreported mechanistic pathway may be applied to other light-induced transformations performed in DMSO in the presence of bases and aryl halides.
PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS
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Page/Page column 40-42, (2021/08/06)
The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases, particularly fungal diseases of agricultural crop plants.
Cerium catalyst promoted C-S cross-coupling: Synthesis of thioethers, dapsone and RN-18 precursors
Tavares Junior, José M. Da C.,Da Silva, Caren D. G.,Dos Santos, Beatriz F.,Souza, Nicole S.,De Oliveira, Aline R.,Kupfer, Vicente L.,Rinaldi, Andrelson W.,Domingues, Nelson L. C.
supporting information, p. 10103 - 10108 (2019/12/23)
In this work, we present a novel, efficient and green methodology for the synthesis of thioethers by the C-S cross-coupling reaction with the assistance of [Ce(l-Pro)2]2Ox as a heterogeneous catalyst in good to excellent yields. A scale-up of the protocol was explored using an unpublished methodology for the synthesis of a dapsone-precursor, which proved to be very effective over a short time. The catalyst [Ce(l-Pro)2]2Ox was recovered and it was shown to be effective for five more reaction cycles.
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: Synthesis, structure-activity relationships, and pharmacokinetics
Ndungu, J. Maina,Krumm, Stefanie A.,Yan, Dan,Arrendale, Richard F.,Reddy, G. Prabhakar,Evers, Taylor,Howard, Randy,Natchus, Michael G.,Saindane, Manohar T.,Liotta, Dennis C.,Plemper, Richard K.,Snyder, James P.,Sun, Aiming
supporting information; experimental part, p. 4220 - 4230 (2012/06/30)
The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric morbidity and mortality worldwide. In an effort to provide therapeutic treatments for improved measles management, we previously identified a small, non-nucl
Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists
Clark, Robin D.,Jahangir, Alam,Severance, Daniel,Salazar, Rick,Chang, Thomas,Chang, David,Jett, Mary Frances,Smith, Steven,Bley, Keith
, p. 1053 - 1056 (2007/10/03)
On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl] amine] had analgesic activity in the rat.
Therapeutic amides
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, (2008/06/13)
Amides having formula I: STR1 wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the amides and pharmaceutical compositions containing them.
MOLECULAR POLARIZABILITY OF ORGANIC COMPOUNDS AND THEIR COMPLEXES. XLIV. CONFORMATIONS OF DIARYL SULFONES IN DIOXANE
Bulgarevich, S. B.,Movshovich, D. Ya.,Ivanova, N. A.,Filippov, S. E.,Finocchiaro, P.,Failla, S.
, p. 379 - 387 (2007/10/02)
We determined molar Kerr constants and dipole moments in dioxane solutions for a number of diaryl sulfones with various substituents in the aromatic nuclei.The data obtained were analyzed to establish the preferential molecular conformations.It was shown that diaryl sulfones occur in solution mainly in the form of orthogonal or planar-orthogonal conformers, or as an equilibrium between these two.In the orthogonal conformer both aromatic rings are perpendicular to the plane of the CArSCAr bonds, whereas in the planar-orthogonal conformer one ring is coplanar and the other orthogonal to this plane.The orthogonal orientation of aromatic rings relative to the CArSCAr plane originates from the ?-conjugation of the nuclei and the sulfonyl gruop of the sulfone molecules.
Conformational investigation of diarylsulphides by Kerr effect and dipole moment methods
Bulgarevich, S. B.,Movshovich, D. Ya.,Ivanova, N. A.,Finocchiaro, P.,Failla, S.
, p. 207 - 222 (2007/10/02)
Molar Kerr constants and electric dipole moments are reported for (4-NO2C6H4)2S, (4-MeOC6H4)2S, (4-MeOC6H4)(4'-NO2C6H4)S, (2-MeOC6H4)(4'-NO2C6H4)S, (4-MeOC6H4)(2'-NO2C6H4)S, (2-MeOC6H4)(2'-NO2C6H4)S and (4-ClC6H4)2SO as solutes in dioxane at 298 K.The data are analysed in terms of the preferred conformations adopted in solution.In most cases these data are consistent with the presence, in dioxane, of helical conformers, where both aromatic rings are twisted in the same direction with respect to the CAr-S-CAr molecular reference plane.The (4-ClC6H4)2SO molecule adopts an orthogonal conformation where both aryl rings are approximately perpendicular to the CAr-S-CAr molecular reference plane.
Conformational investigation of diarylsulphones by Kerr effect and dipole moment methods
Bulgarevich, S. B.,Movshovich, D. Ya.,Ivanova, N. A.,Filippov, S. E.,Finocchiario, P.,Failla, S.
, p. 365 - 376 (2007/10/02)
Molar Kerr constants and electric dipole moments are reported for (C6H5)2SO2, (4Cl-C6H4)(C6H5)SO2, (2,4,6-Me3C6H2)(4'-Br-C6H4)SO2, (4-NO2C6H4)2SO2, (4-MeOC6H4)(4'-NO2C6H4)SO2, (2-MeOC6H4)(4'-NO2C6H4)SO2, (2-NO2C6H4)(4'-MeOC6H4)SO2 and (2-MeOC6H4)(2'-NO2C6H4)SO2 as solutes in dioxane solution at 298 K.The data are analysed in terms of the preferred conformations adopted in solution.In most cases these data are consistent with the presence, in dioxane, of orthogonal or planar-orthogonal conformers, or of a mixture of them.In the orthogonal rotamer both aromatic rings are approximately perpendicular to the CAr-S-CAr molecular reference plane whereas in the planar-orthogonal conformer one ring is coplanar and the other is orthogonal to the reference CAr-S-CAr plane.
