92074-28-7Relevant articles and documents
Iron-Catalyzed Regiodivergent Hydrostannation of Alkynes: Intermediacy of Fe(IV)-H versus Fe(II)-Vinylidene
Liu, Jianguo,Song, Heng,Wang, Tianlin,Jia, Jiong,Tong, Qing-Xiao,Tung, Chen-Ho,Wang, Wenguang
supporting information, p. 409 - 419 (2021/01/12)
We report an iron system, Cp*Fe(1,2-R2PC6H4X), which controls the Markovnikov and anti-Markovnikov hydrostannation of alkynes by tuning the ionic metal-heteroatom bonds (Fe-X) reactivity. The sequential addition of nBu3SnH to the iron-amido catalyst (1, X = HN-, R = Ph) affords a distannyl Fe(IV)-H species responsible for syn-addition of the Sn-H bond across the CC bond to produce branched α-vinylstannanes. Activation of the C(sp)-H bond of alkynes by an iron-aryloxide catalyst (2, X = O-, R = Cy) affords an iron(II) vinylidene intermediate, allowing for gem-addition of the Sn-H to the terminal-carbon producing β-vinylstannanes. These catalytic reactions exhibit excellent regioselectivity and broad functional group compatibility and enable the large-scale synthesis of diverse vinylstannanes. Many new reactions have been established based on such a synthetic Fe-X platform to demonstrate that the initial step of the catalysis is conveniently controlled by the activation of either the tin hydride or the alkyne substrate.
SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF
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Page/Page column 76, (2021/11/06)
Provided herein are compounds of Formula (I), methods of using the compounds as SHP2 inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating SHP2-mediated diseases.
Non-Pd transition metal-catalyzed hydrostannations: Bu3SnF/PMHS as a tin hydride source
Maleczka Jr., Robert E.,Ghosh, Banibrata,Gallagher, William P.,Baker, Aaron J.,Muchnij, Jill A.,Szymanski, Amy L.
, p. 4000 - 4008 (2013/06/27)
Molybdenum, cobalt, nickel, ruthenium, and rhodium catalyzed alkyne hydrostannations using in situ generated Bu3SnH were studied. In most cases, Bu3SnF+polymethylhydrosiloxane (PMHS) performed well as the in situ source of Bu3/
Ruthenium-catalysed hydrogenation of alkynylstannanes with migration of the stannyl group
Shirakawa, Eiji,Morita, Ryotaro,Tsuchimoto, Teruhisa,Kawakami, Yusuke
, p. 13614 - 13615 (2007/10/03)
Molecular hydrogen adds to aliphatic and aromatic alkynylstannanes in the presence of a ruthenium catalyst, pushing the stannyl group to the adjacent carbon atom to give α-substituted vinylstannanes. This is the first achievement of hydrogenation of alkynylstannanes, which is applicable also to the deuteration affording precursors for an important class of deuterium-labeled compounds. Copyright
Stannyl-cupration of Acetylenes and the Reaction of the Intermediate Cuprates with Electrophiles as a Synthesis of Substituted Vinylstannanes
Barbero, Asuncion,Cuadrado, Purificacion,Fleming, Ian,Gonzalez, Ana M.,Pulido, Francisco J.,Rubio, Rosa
, p. 1657 - 1662 (2007/10/02)
Stannyl-cupration of acetylenes followed by electrophilic attack with a variety of electrophiles gives E-vinylstannanes.These can be used either to form acetylenes, thus achieving overall the addition of an ethynyl group, or to form carbon-carbon bonds in Stille reactions.
(Trialkylstannyl)dimethylsilane as a New Precursor of Dimethylsilylene: A Novel Synthesis of 3,4-Disubstituted 1-Silacyclopenta-2,4-dienes
Ikenaga, Kazutoshi,Hiramatsu, Kouji,Nasaka, Norimitsu,Matsumoto, Satoshi
, p. 5045 - 5047 (2007/10/02)
In the presence of triphenylphosphinepalladium complexes, (trialkylstannyl)dimethylsilane rapidly reacted at room temperature with terminal acetylenes to give 3,4-disubstituted 1-silacyclopenta-2,4-dienes in moderate yield.The formation of 1-silacyclopentadiene derivatives is evidence for the generation of dimethylsilylene species from (trialkylstannyl)dimethylsilane.
The Stannyl-Cupration of Acetylenes and the Reaction of the Intermediate Cuprates with Electrophiles as a Synthesis of Substituted Vinylstannanes
Barbero, Asuncion,Cuadrado, Purificacion,Fleming, Ian,Gonzalez, Ana M.,Pulido, Francisco J.
, p. 351 - 353 (2007/10/02)
Stannyl-cupration of acetylenes followed by electrophilic attack with a variety of electrophiles gives vinylstannanes.
Regioselective Hydrostannation of Terminal Acetylenes under Transition Metal Catalysis
Kikukawa, Kiyoshi,Umekawa, Hideto,Wada, Fumio,Matsuda, Tsutomu
, p. 881 - 884 (2007/10/02)
Rhodium complexes (RhClL3, RhCl(CO)L2, 2; L = PPh3) catalyze hydrostannation of terminal acetylenes (RCCH; R = Ph, Me3Si, R1OC(R2)R3), and R1OCH2CH2; R1 = THP, OAc; R1, R
Synthese et thermolyse eclair d'esters α-tributylstanniques
Duboudin, J. Georges,Ratier, Max,Trouve, Bruno
, p. 181 - 192 (2007/10/02)
The preparation of some alkyltributyltin acetates and thiocarbonates is described.Flash thermolysis of these compounds at high temperature (600-950 deg C) and under a moderate vacuum, provides a new route to vinyltributyltin derivatives.
A NEW ROUTE TO VINYLTRIBUTYLTIN COMPOUNDS BY FLASH PYROLYSIS OF ALKYLTRIBUTYLTIN ACETATES
Duboudin, J. Georges,Petraud, Michel,Ratier, Max,Trouve, Bruno
, p. C6 - C8 (2007/10/02)
Flash pyrolysis of alkyltributyltin acetates, at high temperatures (600-850 deg C) under a moderate vacuum provides a convenient route to vinyltin derivatives.
