103185-03-1

Upstream product

• 50-00-0 formaldehyd 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 3156-07-8 methyl phenyl ketene 
• 4456-36-4 di(p-methoxyphenyl)tellurium dichloride 
• 201230-82-2 carbon monoxide 
• 92074-28-7 1-phenyl-1-(tributylstannyl)ethene 
• 959-23-9 4'-methoxychalcone 
• 93011-61-1 3-(4-methoxyphenyl)-3-oxo-2-phenylpropanal 
• 40327-51-3 1-(p-methoxyphenyl)-3-phenyl-2,3-epoxy-1-propanone 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 103-82-2 phenylacetic acid 
• 95092-10-7 N-methoxy-N-methyl-2-phenylacetamide 
• 5739-38-8 1-(4-methoxyphenyl)-3-phenylpropan-1-one 

Downstream Products

• 27536-36-3 1-(4-methoxy-phenyl)-2-phenyl-3-piperidin-1-yl-propan-1-one 
• 855613-52-4 (4-methoxy-phenyl)-[6-(4-methoxy-phenyl)-2,5-diphenyl-3,4-dihydro-2H-pyran-2-yl]-ketone 
• 116375-64-5 3-(tert-Butyl-hydroxy-amino)-1-(4-methoxy-phenyl)-2-phenyl-propan-1-one 
• 855911-66-9 2-hydroxy-1,6-bis-(4-methoxy-phenyl)-2,5-diphenyl-hexane-1,6-dione 

Relevant academic research and scientific papers

Palladium- and copper-catalyzed cross-coupling and carbonylative cross-coupling of organotellurium compounds with organostannanes

The palladium- and copper-catalyzed cross-coupling of diaryl- or divinyl tellurium dichlorides with organostannanes has been achieved in the presence of PdCl2 (10 mol%) or CuI (10 mol%) with Cs2CO3 (2 equiv.) in MeCN in good to moderate yields; alternatively, the palladium- and copper-catalyzed carbonylative cross-coupling of organotellurium dichlorides with organostannanes was readily accomplished under atmospheric pressure of CO in good to moderate yields.

Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents

An enantioselective epoxidation of α-substituted vinyl ketones was realized to construct the key epoxide intermediates for the synthesis of various triazole antifungal agents. The reaction proceeded efficiently in high yields with good enantioselectivities by employing a chiral N,N′-dioxide/ScIII complex as the chiral catalyst and 35% aq. H2O2 as the oxidant. It enabled the facile transformation for optically active isavuconazole, efinaconazole, and other potential antifungal agents.

Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds

Azidation of alkenes is an efficient protocol to synthesize organic azides which are important structural motifs in organic synthesis. Enantioselective radical azidation, as a useful strategy to install a C-N3 bond, remains challenging due to the inherently instability and unique structure of radicals. Here, we disclose an efficient enantioselective radical carboazidation and diazidation of α,β-unsaturated ketones and amides catalyzed by chiral N,N′-dioxide/Fe(OTf)2 complexes. An array of substituted alkenes was transformed to the corresponding α-azido carbonyl derivatives in good to excellent enantioselectivities, benefiting the preparation of chiral α-amino ketones, vicinal amino alcohols, and vicinal diamines. Control experiments and mechanistic studies proved the radical pathway in the reaction process. The DFT calculations showed that the azido transferred to the radical intermediate via an intramolecular five-membered transition state with the internal nitrogen of the Fe-N3 species.

Formal Enone α-Arylation via I(III)-Mediated Aryl Migration/Elimination

A formal enone α-arylation is described. This metal-free transformation relies on the I(III)-mediated skeletal reorganization of silyl enol ethers and features mild conditions, good yields, and high stereoselectivities for β-substituted enones.

A methylene compound of preparation method and its application (by machine translation)

The invention discloses a methylene compound of preparation method and its application, relates to the field of organic synthesis, the process comprises: 1) in the presence of a three-valent metal salt catalyst, will arone compound and halogen methyl radical trialkyl ammonium salt dissolved in a solvent, 2) 80 - 130 °C reaction 1 - 4 hours, separated and purified α - the methyl radical is fragrant compounds, the reaction environment pollution is small, substrate and wide range of application. (by machine translation)

Metal-free, one-pot, sequential protocol for transforming ,-epoxy ketones to -hydroxy ketones and -methylene ketones

A new sequential, one-pot protocol for transforming 1,3-disubstituted 2,3-epoxy ketones to β;-hydroxy ketones and α-methylene ketones has been developed. Reaction of epoxy ketones with boron trifluoride etherate (BF3·OEt2) generates the cationic intermediates by regioselective epoxide ring opening and an acyl shift. Then, a treatment of these cations with 2-aryl-1,3-dimethylbenzimidazolines (DMBIH) results in formation of 1,2-disubstituted 3-hydroxy ketones. DMBIH serves as a hydride donor in the second step of this process. Finally, the β;-hydroxy ketones can be converted to 1,2-disubstituted 2-methylene ketones by treatment with methanesulfonic acid or a combination of methanesulfonyl chloride and triethylamine. Importantly, the sequential steps involved in formation of the α-methylene ketone products can be carried out in one pot.

Novel Synthesis of α,β-Unsaturated Ketones by the Palladium-Catalyzed Arylation of Ketenes with Aroyl Chlorides or the Decarbonylative Cross-Condensation of Acyl Halides

The reaction of alkylphenylketene with aroyl chlorides or the decarbonylative cross-condensation reaction of α-phenylacetyl chlorides with aroyl chlorides in the presence of triethylamine and a catalytic amount of a palladium complex gives α,β-unsaturated

PALLADIUM COMPLEX CATALYZED SYNTHESIS OF α,β-UNSATURATED KETONES FROM ALKYLPHENYLKETENE AND AROYL CHLORIDE

α,β-Unsaturated ketones were obtained from alkylphenylketene and aroyl chloride via decarbonylation reaction in the presence of catalytic amounts of tetrakis(triphenylphosphine) palladium.