92103-31-6

Upstream product

• 536-74-3 phenylacetylene 
• 106-54-7 p-Chlorothiophenol 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 873-73-4 4-n-chlorophenylacetylene 
• 637-44-5 phenylpropyolic acid 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 65264-00-8 4-chloromophenyl 4'-methylphenyl disulfide 
• 5138-90-9 sodium 4-chlorobenzenesulfonate 
• 103-64-0 bromostyrene 
• 70998-28-6 p-chlorophenyl 2-phenylethyl sulfide 
• 18803-44-6 sodium p-chlorothiophenolate 
• 933-01-7 4-chloro-benzenesulfenyl chloride 
• 42599-24-6 E-styryl iodide 
• 100-42-5 styrene 

Downstream Products

• 32291-78-4 p-Chlorphenyl-cis-styrylsulfon 
• 32228-21-0 (E)-(styryl)(4-chloro-phenyl)sulfide 
• 16215-12-6 (E)-1-chloro-4-(styrylsulfonyl)benzene 
• 482648-13-5 trans-Pt[(E)-C(H)C(H)(Ph)](S(C₆H₄Cl-p))(PPh₃)2 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 122-78-1 phenylacetaldehyde 
• 33105-34-9 (E)-1-triphenylsilyl-2-phenylethene 
• 16212-08-1 1-methyl-4-[(E)-2-phenylethenesulfonyl]benzene 
• 3582-84-1 (2-phenylethyl)diphenylphosphine oxide 

Relevant academic research and scientific papers

Potassium tert -Butoxide Mediated Reductive C-P Cross-Coupling of Arylvinyl Sulfides through C-S Bond Cleavage

A transition-metal-free t -BuOK-mediated reductive C-P cross-coupling reaction of arylvinyl sulfides with diarylphosphine oxides through C-S bond cleavage has been developed. This protocol not only permits the synthesis of diaryl(2-arylethyl)phosphine oxides, but also achieves an unprecedented construction of a C-P bond through C-S bond cleavage and reduction of a C-C double bond in one pot.

Site-Selective Acceptorless Dehydrogenation of Aliphatics Enabled by Organophotoredox/Cobalt Dual Catalysis

The value of catalytic dehydrogenation of aliphatics (CDA) in organic synthesis has remained largely underexplored. Known homogeneous CDA systems often require the use of sacrificial hydrogen acceptors (or oxidants), precious metal catalysts, and harsh reaction conditions, thus limiting most existing methods to dehydrogenation of non- or low-functionalized alkanes. Here we describe a visible-light-driven, dual-catalyst system consisting of inexpensive organophotoredox and base-metal catalysts for room-temperature, acceptorless-CDA (Al-CDA). Initiated by photoexited 2-chloroanthraquinone, the process involves H atom transfer (HAT) of aliphatics to form alkyl radicals, which then react with cobaloxime to produce olefins and H2. This operationally simple method enables direct dehydrogenation of readily available chemical feedstocks to diversely functionalized olefins. For example, we demonstrate, for the first time, the oxidant-free desaturation of thioethers and amides to alkenyl sulfides and enamides, respectively. Moreover, the system's exceptional site selectivity and functional group tolerance are illustrated by late-stage dehydrogenation and synthesis of 14 biologically relevant molecules and pharmaceutical ingredients. Mechanistic studies have revealed a dual HAT process and provided insights into the origin of reactivity and site selectivity.

A Simplified Protocol for the Stereospecific Nickel-Catalyzed C-S Vinylation Using NiX 2 Salts and Alkyl Phosphites

A Ni-catalyzed C-S cross-coupling using only NiI 2 (0.5-2.5 molpercent) and P(O i Pr) 3 (2.0-10.0 molpercent) is reported. Using an air-stable Ni(II) precatalyst, and a cheap and commercially available ligand, a scalable and robust method was developed to cross-couple various thiophenols and styryl bromides, including some sterically encumbered thiols, an α-bromocinnamaldehyde as well as a thiolation-cyclization.

Electrophilic Vinylation of Thiols under Mild and Transition Metal-Free Conditions

The iodine(III) reagents vinylbenziodoxolones (VBX) were employed to vinylate a series of aliphatic and aromatic thiols, providing E-alkenyl sulfides with complete chemo- and regioselectivity, as well as excellent stereoselectivity. The methodology displays high functional group tolerance and proceeds under mild and transition metal-free conditions without the need for excess substrate or reagents. Mercaptothiazoles could be vinylated under modified conditions, resulting in opposite stereoselectivity compared to previous reactions with vinyliodonium salts. Novel VBX reagents with substituted benziodoxolone cores were prepared, and improved reactivity was discovered with a dimethyl-substituted core.

Alkenyl preparation method of sulfide

The invention discloses a method for preparing alkenyl sulfide. The method comprises the following steps: adding a styrene derivative of the formula I as shown in the specification into a disulfide compound of the formula II as shown in the specification,

Sulfamic acid: An efficient and recyclable catalyst for the regioselective hydrothiolation of terminal alkenes and alkynes with thiols

Herein, we described a new method for the preparation of thioethers through hydrothiolation of alkenes and alkynes, using sulfamic acid as a reusable catalyst. Generally, this new methodology afforded the desired products in very good yields, under metal

Acid/Phosphide-Induced Radical Route to Alkyl and Alkenyl Sulfides and Phosphonothioates from Sodium Arylsulfinates in Water

A newly developed aqueous system with acid and phosphide was introduced in which odorless and stable sodium arylsulfinates can in situ generate arylsulfenyl radicals. These radicals have high reactivity to react with alkynes, alkenes, and H-phosphine oxides for the synthesis of alkyl and alkenyl sulfides and phosphonothioates. The control experiments and quantum calculations are also performed to gain insights into the generation mechanism of arylsulfenyl radicals. Notably, the chemistry is free of thiol odors, organic solvents, and metals.

Stereoselective Synthesis of Alkenyl Silanes, Sulfones, Phosphine Oxides, and Nitroolefins by Radical C-S Bond Cleavage of Arylalkenyl Sulfides

A radical-mediated approach has been introduced for the C-S bond activation of arylalkenyl sulfides. The protocol provides an efficient approach for the generation of various alkenes including alkenyl silanes, sulfones, phosphine oxides, and nitroolefins. In most cases, these radical substitutions are performed under metal-free conditions with stereospecificity.

Synthesis method of diaryl sulfide

The invention relates to a synthesis method of diaryl sulfide shown by Formula (III) below. The method comprises the following steps: in a nitrogen atmosphere, reacting compounds shown by Formulae (I) and (II) below in reaction solvent in the presence of a catalyst, an organic ligand, alkali and assistants; after the reaction is completed, performing post treatment to obtain the compound shown by Formula (III), wherein R1 and R2 are independently selected from H, C1-C6 alkyl or halogen; and X is halogen. According to the method, the target product can be obtained at a high yield by appropriately selecting the reaction materials in combination with the comprehensive cooperation and promotion of the specific catalyst, alkali, ligand and assistants. Thus, a brand new method is provided for synthesis of the compounds, and the method has favorable application prospects and scientific research value in the organic synthesis field.

Copper-mediated stereospecific C-H oxidative sulfenylation of terminal alkenes with disulfides

A copper and iodine-mediated C-H oxidative sulfenylation of olefins with diaryl disulfides has been developed for the stereospecific synthesis of vinyl thioether. With the combination of Cu(OTf)2 and I2, a variety of terminal alkenes