92152-98-2

Usage

Type of compound

Ketone derivative

Class of organic compounds

Acetophenone

Chirality

Chiral compound

Medical use

Anorectic or appetite suppressant

Treatment target

Obesity

Mechanism of action

Increases release of norepinephrine and dopamine in the brain

Effects

Reduced appetite and increased energy expenditure

Potential side effects

Insomnia, palpitations, and elevated blood pressure

Caution

Use with caution and under the supervision of a healthcare professional

Upstream product

• 2444-36-2 2'-chloro-benzeneacetic acid 
• 108-90-7 chlorobenzene 
• 122-01-0 4-chloro-benzoyl chloride 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 139326-89-9 N-(4-chlorobenzyl)-pyridinium bromide 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 623-03-0 4-Cyanochlorobenzene 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 

Downstream Products

• 7504-28-1 1-chloro-2-((4-chlorophenyl)ethynyl)benzene 
• 935456-45-4 1-(4-chlorophenyl)-2-(2-chlorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one 
• 94148-01-3 2-(2-chlorophenyl)-3-(4-chlorophenyl)-prop-1-en-3-one 
• 1202017-82-0 2-(4-chloro-phenyl)-3-(2-chloro-phenyl)-6-(2H-tetrazol-5-ylmethyl)-pyridine-5-carboxylic acid [(R)-1-(2-fluoro-phenyl)-ethyl]-amide 
• 1202017-69-3 2-(4-chloro-phenyl)-3-(2-chloro-phenyl)-6-cyanomethyl-pyridine-5-carboxylic acid [(R)-1-(2-fluoro-phenyl)-ethyl]-amide 
• 1202017-67-1 2-(4-chloro-phenyl)-3-(2-chloro-phenyl)-6-cyanomethyl-pyridine-5-carboxylic acid 
• 1202017-68-2 2-(4-chloro-phenyl)-3-(2-chloro-phenyl)-6-cyanomethyl-pyridine-5-carboxylic acid chloride 
• 92153-28-1 2.4'-Dichlor-benzilsaeure 
• 25144-40-5 (E)-1-chloro-2-(4-chlorostyryl)benzene 
• 92291-61-7 1-<4-Chlorphenyl>-2-<2-chlorphenyl>-aethanol 
• 55510-24-2 1-(2-chlorophenyl)-2-(4-chlorophenyl)ethane-1,2-dione 

Relevant academic research and scientific papers

New preparation of benzylic manganese chlorides by the direct insertion of magnesium into benzylic chlorides in the presence of MnCl2·2LiCl

Functionalized benzylic manganese chlorides were smoothly prepared by the direct insertion of magnesium into benzylic chlorides in the presence of MnCl2·2LiCl. Reactions with acid chlorides, aldehydes, an allyl bromide, and an enone proceed without any additional transition metal.

Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines

The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway.

A PYRAZOLO[1,5-A]PYRIMIDINE COMPOUND

The present invention provides a pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of the following formula [I]: in which R1 and R2 are the same or different and each an optionally substituted aryl group etc, R0 is hydrogen atom, an alkyl group etc, E is a group of the formula: -C(=O)- or -SO?2#191-, R is a group of the following formula [i], [ii] or [iii] etc: Ring A is (a) a C?3-8#191 cycloalkyl group optionally fused to a benzene ring or (b) a benzene ring, Q is a single bond or a methylene group, Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom etc, R3 is an alkyl group optionally substituted by an alkylthio group, R4 is hydrogen atom, an alkyl group etc, one of RA and RB is an alkyl group etc, and the other is hydrogen atom, an alkyl group etc, or a pharmaceutically acceptable salt thereof.

An efficient and time saving microwave-assisted selenium dioxide oxidation of 1,2-diarylethanones

Selenium dioxide oxidation of 1,2-diarylethanones to corresponding diones by conventional method takes upto 8 hr. The same oxidation under microwave radiations using dimethylsulfoxide as solvent reduces the reaction time considerably (30 to 90 sec). The method reported is efficient and time saving.

Synthesis of novel substituted diaryl-1,4-diazepines

In this paper a convenient route to new 2,3-diaryl-substituted 1,4-diazepines is described through cyclization of ethanedione derivatives and 1,3-propanediamine. The ethanedione derivatives required were synthesized by microwave-assisted oxidation from ethanones.

5,6-Phenyl-2,3-dihydroimidazo [2,1-b] thiazoles

The compounds are 5,6-phenyl-2,3-dihydroimidazo[2,1-b]thiazoles which have antiarthritic activity. A preferred compound is 5,6-bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole.