92674-40-3

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 201230-82-2 carbon monoxide 
• 780-69-8 triethoxyphenylsilane 
• 98-86-2 acetophenone 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 1414852-68-8 2-benzoyl-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione 
• 1311484-52-2 MIDA alkenyl-2-boronate 
• 100-52-7 benzaldehyde 
• 17763-67-6 Phenyl triflate 
• 109299-78-7 pyrimidine 5-boronic acid 
• 640-60-8 toluene-4-sulfonic acid phenyl ester 
• 126230-69-1 5-<1-Hydroxy-1-(phenyl)methyl>pyrimidine 

Relevant academic research and scientific papers

Suzuki coupling of aroyl-MIDA boronate esters – A preliminary report on scope and limitations

Recent methodological reports for synthesizing acyl-MIDA boronate esters compel an investigation of their potential use as substrates in a standard Suzuki-Miyaura cross-coupling reaction. Here we report the production of benzophenones by C[sbnd]C cross coupling between a benzoyl-MIDA boronate ester and a multitude of aryl bromide substrates in adequate yields following optimization under ambient conditions outside of a glove box. Under these standard conditions, none of several acyl-MIDA boronate esters (in an alkyl series) serves as a competent coupling partner. The substrate scope is also limited by the finding that the corresponding trifluoroborates of both acyl- and aroyltrifluroborates are not suitable substrates. For reasons of availability and synthetic difficulty in procuring other aroyl-MIDA boronates, this preliminary study examines the reactivity of benzoyl-MIDA boronate with several aryl bromide substrates.

Synthetic method of OLED material intermediate benzoyl pyrimidine compound

The invention discloses a synthetic method of an OLED material intermediate benzoyl pyrimidine compound. The synthetic method comprises the following steps: mixing alkali, a solvent I as well as substituent acetophenone and oxalic acid diester which are u

Method for preparing diaryl ketone from aryl sulfonate

The invention discloses a method for preparing diaryl ketone from aryl sulfonate. The method includes following steps: in the presence of a catalyst and carbon monoxide, allowing aryl sulfonate and aryl boronic acid to react in an organic solvent; after reaction is finished, performing aftertreatment to obtain diaryl ketone. Aryl sufonate is adopted as an electrophilic reagent for Suzuki cross carbonylation coupling reaction, diaryl ketone is directly synthesized through carbon monoxide, aryl sulfonate and aryl boronic acid, reaction conditions are milk, functional groups are high in tolerance, a substrate is cheap and easy to get, and diaryl ketone can be prepared with high yield.

Carbonylative coupling of aryl tosylates/triflates with arylboronic acids under CO atmosphere

The carbonylative Suzuki-Miyaura reaction between aryl tosylates/triflates with arylboronic acid is herein reported, using base-free conditions and a balloon pressure of carbon monoxide. Under these conditions, unsymmetrical biaryl ketones were obtained in modest to excellent yields. This method was adapted to the synthesis of oxybenzone and ketoprofen in good yields under mild conditions.

Carbonylative Hiyama coupling of aryl halides with arylsilanes under balloon pressure of CO

An efficient protocol has been developed for the carbonylative Hiyama coupling of aryl halides using the cesium fluoride as a promoter by palladium-catalyzed in NMP. This protocol was applied to a wide variety of functionalized and hindered aryl iodides and bromides with arylsilanes, to afford the desired biaryl ketones in good to excellent yields.

Aryl diazinyl ketoximes: Synthesis and configurational assignment

Preparation of a series of new aryl diazinyl ketoximes (7a,b - 12a,b) required as synthetic building blocks is described. Separation of the E/Z-isomers obtained was achieved by means of chromatography, their configuration was assigned using nmr techniques. Moreover, procedures for the synthesis of the starting ketones (1b - 6b) are given.