936114-12-4

Basic information

• Product Name: potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate
• Synonyms: potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate
• CAS NO: 936114-12-4
• Molecular Weight: 726.919
• Mol File: 936114-12-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate(936114-12-4)
• EPA Substance Registry System: potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate(936114-12-4)

Safety Data

• Hazardous Substances Data: 936114-12-4(Hazardous Substances Data)

Upstream product

• 144690-33-5 ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate 
• 106-38-7 para-bromotoluene 
• 168265-56-3 1-benzyl-5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole 
• 144689-23-6 ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate 
• 38612-13-4 4-bromobenzyl benzoate 
• 28386-90-5 5-benzyl-1-phenyl-1H-tetrazole 
• 1485-70-7 N-benzylbenzamide 
• 98-88-4 benzoyl chloride 
• 124750-51-2 N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole 
• 144689-93-0 ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate 

Downstream Products

• 144690-92-6 trityl olmesartan medoxomil 
• 144689-63-4 olmesartan medoxomil 

Relevant articles and documents

Preparation and purification method for triphenyl methyl olmesartan compound (I)

The present invention provides a preparation and purification method for triphenyl methyl olmesartan. The method comprises the following steps: forming a triphenyl methyl olmesartan carboxylate reaction liquid by using ethyl 4-(2-hydroxy-2-propanyl)-2-pro

METHOD FOR PRODUCING BIARYL COMPOUND

Provided is a novel production method capable of producing a biaryl compound, which is useful as an intermediate for angiotensin II receptor blockers, economically under conditions suitable for industrial production. A production method of a biaryl compound of the formula [3] or a salt thereof, including reacting a 2-phenylazole derivative of the formula [1] or a salt thereof, with a benzene derivative of the formula [2] or a salt thereof in the presence of a metal catalyst, a base, and one or more kinds of compounds selected from the group consisting of (a) a monocarboxylic acid metal salt, (b) a dicarboxylic acid metal salt, (c) a sulfonic acid metal salt, and (d) a phosphate or phosphoric amide metal salt represented by RAxP(O)(OM)y wherein each symbol is as defined in the DESCRIPTION.

A METHOD OF REMOVING THE TRIPHENYLMETHANE PROTECTING GROUP FROM PRECURSORS OF ANTIHYPERTENSIVE DRUGS

A method of removing the triphenylmethane protecting group from precursors of antihypertensive drugs of general formula I, wherein R is a metabolically degradable group, B is a heterocyclic moiety with one or two 5- or 6-membered rings at least one of which contains two nitrogen heteroatoms, in which the compound of formula I is reacted with water in the presence of a solvent which is partially or completely miscible with water.