93852-40-5

Usage

Chemical Properties

White Solid

Uses

An intermediate in the synthesis of Reboxetine (R142000).

InChI:InChI=1/C19H22ClNO4/c1-2-24-16-10-6-7-11-17(16)25-19(14-8-4-3-5-9-14)15(22)13-21-18(23)12-20/h3-11,15,19,22H,2,12-13H2,1H3,(H,21,23)

Upstream product

• 1055175-79-5 (2RS,3RS)-1,2-Epoxy-3-(2-ethoxyphenoxy)-3-phenylpropane 
• 79-04-9 chloroacetyl chloride 
• 93852-37-0 (2-Ethoxy-phenoxy)-phenyl-acetic acid 
• 135766-73-3 (2-Ethoxy-phenoxy)-phenyl-acetic acid ethyl ester 
• 133534-26-6 2-hydroxy-3-(2-ethoxyphenoxy)-3-benzenepropanenitrile 
• 133534-40-4 (2-Ethoxy-phenoxy)-phenyl-acetaldehyde 
• 10606-73-2 ethyl 2-chloro-2-phenylacetate 
• 94-71-3 2-Ethoxyphenol 
• 93853-03-3 (2RS,3RS)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 98769-69-8 (2RS,3SR)-3-(2-ethoxyphenoxy)-1,2-dihydroxy-3-phenylpropane 
• 98769-73-4 (2RS,3SR)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenyl-1-tosyloxypropane 
• 40641-81-4 trans-2,3-epoxy-3-phenylpropan-1-ol 
• 93851-63-9 (2RS,3SR)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 

Downstream Products

• 93851-85-5 2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine; hydrochloride 
• 93886-32-9 (2RS,3RS)-2-[α-(2-Ethoxyphenoxy)benzyl]morpholine-5-one 
• 104968-70-9 (S,S)-reboxetine (S)-mandelate 

Relevant academic research and scientific papers

Method for the preparation of aryl ethers

The invention relates to a method for preparing aryl ethers that are useful as antidepressants. The invention also relates to intermediates useful in the method and to methods for preparing such intermediates.

Potential antidepressant agents. α-Aryloxy-benzyl derivatives of ethanolamine and morpholine

Various α-aryloxy-benzyl derivatives of ethanolamine and morpholine were synthesized and tested as potential antidepressant agents. A morpholine derivative, the 2-[α-(2-ethoxy-phenoxy) benzyl]morpholine, showed outstanding activity in the antireserpine te