93853-03-3

Basic information

• Product Name: (2RS,3RS)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine
• Synonyms: (2RS,3RS)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine
• CAS NO: 93853-03-3
• Molecular Weight: 287.359
• Mol File: 93853-03-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2RS,3RS)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (2RS,3RS)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine(93853-03-3)
• EPA Substance Registry System: (2RS,3RS)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine(93853-03-3)

Safety Data

• Hazardous Substances Data: 93853-03-3(Hazardous Substances Data)

Upstream product

• 98769-72-3 (2RS,3RS)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide 
• 98769-70-1 (2RS,3SR)-3-(2-ethoxyphenoxy)-2-hydroxy-1-(4-nitrobenzoyloxy)-3-phenylpropane 
• 104-54-1 3-Phenylpropenol 
• 1055175-79-5 (2RS,3RS)-1,2-Epoxy-3-(2-ethoxyphenoxy)-3-phenylpropane 
• 135766-73-3 (2-Ethoxy-phenoxy)-phenyl-acetic acid ethyl ester 
• 133534-40-4 (2-Ethoxy-phenoxy)-phenyl-acetaldehyde 
• 10606-73-2 ethyl 2-chloro-2-phenylacetate 
• 94-71-3 2-Ethoxyphenol 
• 93852-37-0 (2-Ethoxy-phenoxy)-phenyl-acetic acid 
• 133534-26-6 2-hydroxy-3-(2-ethoxyphenoxy)-3-benzenepropanenitrile 
• 93853-04-4 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 98769-71-2 (2RS,3SR)-3-(2-ethoxyphenoxy)-2-mesyloxy-1-(4-nitrobenzoyloxy)-3-phenylpropane 
• 98769-69-8 (2RS,3SR)-3-(2-ethoxyphenoxy)-1,2-dihydroxy-3-phenylpropane 

Downstream Products

• 104968-70-9 (S,S)-reboxetine (S)-mandelate 
• 93886-32-9 (2RS,3RS)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 71620-89-8 reboxetine 
• 71620-89-8 (S,S)-reboxetine 
• 105017-38-7 (2R,3R)-reboxetine 
• 635724-55-9 (2S,3S)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine succinate 
• 98819-74-0 N-[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]-2-chloroacetamide 
• 1340546-27-1 (2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate 
• 1340546-25-9 (2R,3R)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine 
• 98819-73-9 (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 93886-32-9 (-)-(2S,3S)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 93851-87-7 Reboxetine mesylate 
• 93851-85-5 2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine; hydrochloride 
• 93886-32-9 (2RS,3RS)-2-[α-(2-Ethoxyphenoxy)benzyl]morpholine-5-one 

Relevant articles and documents

Commercial synthesis of (S,S)-reboxetine succinate: A journey to find the cheapest commercial chemistry for manufacture

The development of a synthetic process for (S,S)-reboxetine succinate, a candidate for the treatment of fibromylagia, is disclosed from initial scale-up to deliver material for registrational stability testing through to commercial route evaluation and subsequent nomination. This entailed evaluation of several alternative routes to result in what would have been a commercially attractive process for launch of the compound.

Method for the preparation of aryl ethers

The invention relates to a method for preparing aryl ethers that are useful as antidepressants. The invention also relates to intermediates useful in the method and to methods for preparing such intermediates.

Configurational studies on 2-[α-(2-ethoxyphenoxy)benzyl]morpholine FCE 20124

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