93853-03-3

Upstream product

• 98769-72-3 (2RS,3RS)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide 
• 104-54-1 3-Phenylpropenol 
• 10606-73-2 ethyl 2-chloro-2-phenylacetate 
• 1055175-79-5 (2RS,3RS)-1,2-Epoxy-3-(2-ethoxyphenoxy)-3-phenylpropane 
• 135766-73-3 (2-Ethoxy-phenoxy)-phenyl-acetic acid ethyl ester 
• 133534-40-4 (2-Ethoxy-phenoxy)-phenyl-acetaldehyde 
• 94-71-3 2-Ethoxyphenol 
• 93852-37-0 (2-Ethoxy-phenoxy)-phenyl-acetic acid 
• 133534-26-6 2-hydroxy-3-(2-ethoxyphenoxy)-3-benzenepropanenitrile 
• 93853-04-4 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate 
• 98769-69-8 (2RS,3SR)-3-(2-ethoxyphenoxy)-1,2-dihydroxy-3-phenylpropane 
• 40641-81-4 trans-2,3-epoxy-3-phenylpropan-1-ol 
• 98769-73-4 (2RS,3SR)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenyl-1-tosyloxypropane 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 

Downstream Products

• 104968-70-9 (S,S)-reboxetine (S)-mandelate 
• 93886-32-9 (2RS,3RS)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 71620-89-8 reboxetine 
• 71620-89-8 (S,S)-reboxetine 
• 105017-38-7 (2R,3R)-reboxetine 
• 1340546-26-0 (2R,3R)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine (S)-(-)-camphanate 
• 635724-55-9 (2S,3S)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine succinate 
• 98819-74-0 N-[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]-2-chloroacetamide 
• 1340546-27-1 (2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate 
• 1340546-25-9 (2R,3R)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine 
• 98819-73-9 (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 93886-32-9 (-)-(2S,3S)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 93851-87-7 Reboxetine mesylate 
• 93886-32-9 (2RS,3RS)-2-[α-(2-Ethoxyphenoxy)benzyl]morpholine-5-one 

Relevant academic research and scientific papers

Commercial synthesis of (S,S)-reboxetine succinate: A journey to find the cheapest commercial chemistry for manufacture

The development of a synthetic process for (S,S)-reboxetine succinate, a candidate for the treatment of fibromylagia, is disclosed from initial scale-up to deliver material for registrational stability testing through to commercial route evaluation and subsequent nomination. This entailed evaluation of several alternative routes to result in what would have been a commercially attractive process for launch of the compound.

Process development and scale-up for (±)-reboxetine mesylate

Redevelopment of the commercial process for the synthesis of (±)-reboxetine methanesulfonate is described. An optimized and efficient process for the synthesis of (±)-reboxetine starting from cinnamyl alcohol was developed. The redeveloped process minimizes impurity formation and utilizes simplified processing to substantially improve process yield and throughput, and is suitable for the efficient synthesis of multiton quantities of reboxetine.

Method for the preparation of aryl ethers

The invention relates to a method for preparing aryl ethers that are useful as antidepressants. The invention also relates to intermediates useful in the method and to methods for preparing such intermediates.

Process for preparation of 3-substituted derivatives of 1-amino-2-hydroxy propane

The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2- hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new

Potential antidepressant agents. α-Aryloxy-benzyl derivatives of ethanolamine and morpholine

Various α-aryloxy-benzyl derivatives of ethanolamine and morpholine were synthesized and tested as potential antidepressant agents. A morpholine derivative, the 2-[α-(2-ethoxy-phenoxy) benzyl]morpholine, showed outstanding activity in the antireserpine te