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Upstream product

• 18039-45-7 2,5-diphenyl-2H-tetrazole 
• 142312-03-6 2-(4-Chloro-phenyl)-4-p-tolyl-2H-oxazol-5-one 
• 142312-02-5 2-(4-methoxyphenyl)-4-(4-methylphenyl)-5(4H)oxazolone 
• 104-85-8 para-methylbenzonitrile 
• 918497-00-4 α-chlorobenzaldehyde phenylhydrazone 
• 13227-01-5 2-amino-2-(4-methylphenyl)acetic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 142312-21-8 N-(4-methoxybenzoyl)-2-(4-methylphenyl)glycine 
• 7118-55-0 4-methyl-N-phenylbenzimidamide 
• 100-47-0 benzonitrile 
• 62-53-3 aniline 
• 34924-43-1 1,3-diphenyl-1,2,4-triazole 
• 104-87-0 4-methyl-benzaldehyde 
• 588-64-7 benzaldehyde phenylhydrazone 

Relevant academic research and scientific papers

An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds

An electro-oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported. This strategy successfully prepared a series of 1,2,4-triazoles in satisfact

Electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles from phenylhydrazine, aldehydes and amines under mild conditions

A simple and convenient method for the electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles with three components of phenylhydrazine, aldehydes and amines has been established. The electrolysis could be smoothly carried out at room temperature without additional strong oxidants and catalysts to afford the target product in good yields. This electrochemical route effectively extends synthetic field of 1,2,4-triazole derivatives.

An electrochemical multicomponent [3 + 1 + 1] annulations to synthesize polysubstituted 1,2,4-triazoles

An electrochemical multicomponent [3 + 1 + 1] annulation used for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed under transition-metal-, acid-, base- and external-oxidant-free conditions. In an undivided cell, a variety of hydrazones and aldehydes smoothly participate in this transformation to furnish a range of substituted 1,2,4-triazoles. The reaction constitutes a new transformation from hydrazones, aldehydes and NH4OAc into 1,2,4-triazoles, providing a unifying, simple and environmentally friendly approach to the currently available methods.

TBHP/TBAI–Mediated simple and efficient synthesis of 3,5-disubstituted and 1,3,5-trisubstituted 1H-1,2,4-triazoles via oxidative decarbonylation of aromatic aldehydes and testing for antibacterial activities

The author has developed a simple, efficient and eco–friendly convenient general method for synthesis of 3,5–disubstituted–1,2,4–triazoles and 1,3,5–trisubstituted–1,2,4–triazoles from 3–monosubstituted–1,2,4–triazoles and 1,3–disubstituted–1,2,4–triazoles respectively using tetrabutylammonium iodide (TBAI) as catalyst and TBHP as oxidant under mid reaction conditions. This method provides structurally diverse 3,5–disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles in good to excellent yields. 3,5–Disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles derivatives are biologically and pharmaceutically active molecules, and therefore, this protocol could be of wide applications in medicinal chemistry and organic chemistry.

Direct Access to 1,3,5-Trisubstituted 1 H -1,2,4-Triazoles from N -Phenylbenzamidines via Copper-Catalyzed Diamination of Aryl Nitriles

A copper-catalyzed formation of C-N/N-N bonds using N-phenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environme

Novel process for synthesis of 1,2,4-triazoles: Ytterbium triflate-catalyzed cyclization of hydrazonyl chlorides with nitriles

A series of 1,3,5-trisubstituted 1,2,4-triazoles were synthesized via the intermolecular cyclization of hydrazonyl chlorides with nitriles catalyzed by ytterbium triflate [Yb(OTf)3]. The amount of catalysis was discussed and Yb(OTf)3 could be reused without loss of activity. Copyright Taylor & Francis, Inc.

OXAZOLONES. PART VI. REACTION OF 5(4H)-OXAZOLONES WITH NITRILE IMINES: SYNTHESIS OF 1H-1,2,4-TRIAZOLES THROUGH CYCLOADDITION

5(4H)-Oxazolones (1) react as dipolarophiles in cycloadditions with nitrile imines generated from tetrazoles (2) in refluxing anisole affording two 1H-1,2,4-triazole derivatives (3) and diarylethylenes (4).