952-43-2

Basic information

• Product Name: 3,6-diisobutyl-2,5-piperazinedione
• CAS NO: 952-43-2
• Molecular Weight: 226.319
• Mol File: 952-43-2.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 3,6-diisobutyl-2,5-piperazinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-diisobutyl-2,5-piperazinedione(952-43-2)
• EPA Substance Registry System: 3,6-diisobutyl-2,5-piperazinedione(952-43-2)

Safety Data

• Hazardous Substances Data: 952-43-2(Hazardous Substances Data)

Upstream product

• 2666-93-5 (S)-Leu-OMe 
• 2743-60-4 L-Leucine ethyl ester 
• 3081-24-1 H-Phe-OEt 
• 2883-36-5 leucylleucine 
• 90-15-3 α-naphthol 
• 56-81-5 glycerol 
• 56-40-6 glycine 
• 328-39-2 LEUCINE 
• 7732-18-5 water 
• 61-90-5 L-leucine 
• 122-39-4 diphenylamine 
• 18869-43-7 DL-leucine methyl ester 
• 60-29-7 diethyl ether 
• 6322-53-8 leucine methyl ester hydrochloride 

Downstream Products

• 114362-39-9 (3S,6S)-1,4-dibenzyl-3,6-diisobutyl-piperazine-2,5-dione 
• 2666-93-5 (S)-Leu-OMe 
• 90891-90-0 (R)-α-Benzylleucin-methylester 
• 90891-83-1 (2R,5S)-2-Benzyl-2,5-diisobutyl-3,6-dimethoxy-2,5-dihydro-pyrazine 
• 90891-84-2 (2R,5S)-2-(2-Benzyloxy-ethyl)-2,5-diisobutyl-3,6-dimethoxy-2,5-dihydro-pyrazine 
• 90104-02-2 (S)-(-)-α-Methylleucine methyl ester 
• 90891-81-9 cis-6-Benzyl-3,6-diisopropyl-2,5-dioxohexahydropyrazine 
• 90891-81-9 trans-6-Benzyl-3,6-diisopropyl-2,5-dioxohexahydropyrazine 
• 114420-46-1 (2S,5S)-1,4-dibenzyl-2,5-diisobutylpiperazine 
• 503-74-2 3-methylbutyric acid 

Relevant articles and documents

Using fast scanning calorimetry to study solid-state cyclization of dipeptide L-leucyl-L-leucine

The possibility of using fast scanning calorimetry (FSC) to study the kinetics of the solid-state cyclization of dipeptide was demonstrated in the present work for the first time. The activation energy and Arrhenius constant of the cyclization of L/

Interfacial supramolecular biomimetic epoxidation catalysed by cyclic dipeptides

We synthesised a library of cis- and trans-cyclic dipeptides and evaluated their efficacy as catalysts in the asymmetric Weitz-Scheffer epoxidation of trans-chalcone. A thorough investigation relying on structure-activity studies and computational studies provided insights into the mechanism of the process. Our results revealed some structural features required for efficient conversion and for introduction of chirality into the product. The cyclic dipeptide acts as a catalyst by templating a supramolecular arrangement at the aqueous-organic interface required for efficient transformations to occur. Among all cyclic dipeptides investigated, cyclo(Leu-Leu) was the most efficient supramolecular catalyst.

Biomimetic epoxidation in aqueous media catalyzed by cyclic dipeptides

We have developed a practical epoxidation of electron-deficient enones in aqueous media using cyclic dipeptides as bioinspired green catalyst. Optimizing the reaction conditions in a triphasic system led to efficient conditions providing epoxides with good enantioselectivities. Depending on the catalyst substituent chirality, both enantiomers are obtained. The cyclic rigidity impacts significantly the enantioselectivity.