95269-22-0Relevant academic research and scientific papers
Photoinduced Oxidative Alkoxycarbonylation of Alkenes with Alkyl Formates
Tang, Wan-Ying,Chen, Ling,Zheng, Ming,Zhan, Le-Wu,Hou, Jing,Li, Bin-Dong
supporting information, p. 3939 - 3943 (2021/05/26)
A photoinduced oxidative alkoxycarbonylation of alkenes initiated by intermolecular addition of alkoxycarbonyl radicals has been demonstrated. Employing alkyl formates as alkoxycarbonyl radical sources, a range of α,β-unsaturated esters were obtained with good regioselectivity and E selectivity under ambient conditions.
Scalable Electrochemical Dehydrogenative Lactonization of C(sp2/sp3)-H Bonds
Zhang, Sheng,Li, Lijun,Wang, Huiqiao,Li, Qian,Liu, Wenmin,Xu, Kun,Zeng, Chengchu
supporting information, p. 252 - 255 (2018/01/17)
A practical, electrochemical method is developed for the direct dehydrogenative lactonization of C(sp2/sp3)-H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature of this newly developed electrochemical process was demonstrated on a 40 g scale following an operationally simple protocol. The remote lactonization of C(sp3)-H bonds would constitute an important synthetic advance toward electrochemical C-O bond formation.
New orally active diphenylmethyl-based ester analogues of dihydroartemisinin: Synthesis and antimalarial assessment against multidrug-resistant Plasmodium yoelii nigeriensis in mice
Chaudhary, Sandeep,Naikade, Niraj K.,Tiwari, Mohit K.,Yadav, Lalit,Shyamlal, Bharti Rajesh K.,Puri, Sunil K.
, p. 1536 - 1541 (2016/07/27)
A new series of ester analogues of artemisinin 8a–f, incorporating diphenylmethyl as pharmacologically privileged substructure, and 8g–j have been prepared and evaluated for their antimalarial activity against multidrug-resistant (MDR) Plasmodium yoelii nigeriensis in Swiss mice via oral route. These diphenylmethyl-based ester analogues 8a–f were found to be 2–4 folds more active than the antimalarial drugs β-arteether 4 and artesunic acid 5. Ester 8a, the most active compound of the series, provided complete protection to the infected mice at 24?mg/kg?×?4?days as well as 12?mg/kg?×?4?days, respectively. In this model β-arteether provided 100% and 20% protection at 48?mg/kg?×?4?days and 24?mg/kg?×?4?days, respectively.
Synthesis of coumarins via PIDA/I2-mediated oxidative cyclization of substituted phenylacrylic acids
Li, Jinming,Chen, Huiyu,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
, p. 4311 - 4320 (2013/04/24)
A variety of functionalized coumarins were synthesized from substituted phenylacrylic acids via PIDA/I2-mediated and irradiation-promoted oxidative carbon-oxygen bond formation. Our studies show that the oxygen in the pendant carboxylic acid group cyclizes favorably to the aryl ring that is cis to it. The main advantages of this method include good functional group tolerance and the transition-metal-free characteristic. The Royal Society of Chemistry 2013.
Synthesis, structure, and reactivity of dicarbene dipalladium complexes
Li, Yunfei,Yang, Longguang,Chen, Qian,Cao, Changsheng,Guan, Pei,Pang, Guangsheng,Shi, Yanhui
, p. 575 - 581 (2013/04/24)
A series of imidazole-based and benzimidazole-based di-NHC dipalladium complexes with alkyl bridges of different chain lengths were prepared. All complexes were fully characterized by NMR spectroscopy and elemental analyses. The crystal structures of three complexes were determined by X-ray diffraction. X-ray studies show the length of linker effects the solid structure of these complexes and π-π stacking plays an important role for the configuration of NHC-Pd-Py subunits. The activity of NHC-palladium complexes was investigated in the mono- and double-Heck reactions, and the imidazole-based palladium complex bearing the shortest ethylene bridge shows the best activity and selectivity in both reactions. Copyright
Controlled mono- and double-Heck reaction catalyzed by a dicarbene dipalladium complex
Li, Yunfei,Liu, Gang,Cao, Changsheng,Wang, Shuzhan,Li, Yuling,Pang, Guangsheng,Shi, Yanhui
, p. 6241 - 6250 (2013/07/27)
The phosphine-free mono- and double-Heck reaction of terminal olefins with electron-deficient and electron-rich aryl halides (iodides and bromides) is described. These reactions are catalyzed by the dicarbene dipalladium complex 1 by controlling the stoichiometry of the aryl halide and the olefine, the loading of the palladium catalyst, as well as using different base, and with or without additive. The procedure of double-Heck reaction allows β,β- diarylation and β,β′-diarylation of terminal olefins and affords trisubstituted olefins in good to excellent yields.
A novel ketone olefination via organozinc reagents in the presence of diphenyl phosphite
Cui, Hua,Li, Ying,Zhang, Songlin
supporting information, p. 2862 - 2869 (2012/11/07)
Carbonyl compounds react with organozinc reagents in the presence of diphenyl phosphite to give the corresponding olefins. A variety of 1,3-dienes and unsaturated esters were obtained in moderate to excellent yields under mild conditions. The Royal Society of Chemistry 2012.
Palladium-catalyzed double arylations of terminal olefins in acetic acid
Xu, Daichao,Lu, Chunxin,Chen, Wanzhi
experimental part, p. 1466 - 1474 (2012/03/08)
A palladium-catalyzed Heck diarylation of terminal olefins under ligand-free conditions in acetic acid is described. This procedure allows double arylation of terminal olefins affording trisubstituted olefins in good to excellent yields. The methodology is applicable to the coupling of both electron-deficient and electron-rich aryl iodides leading to symmetrical and unsymmetrical β,β-diarylated alkenes.
Palladium-catalyzed intramolecular amidation of C(sp2)-H bonds: Synthesis of 4-aryl-2-quinolinones
Inamoto, Kiyofumi,Saito, Tadataka,Hiroya, Kou,Doi, Takayuki
supporting information; experimental part, p. 3900 - 3903 (2010/07/05)
Figure presented A catalytic synthetic approach for the synthesis of 2-quinolinone compounds through a Pd-catalyzed C(sp2)-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the p
Novel compounds, their preparation and use
-
Page/Page column 31, (2010/02/11)
Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be u
