63389-22-0

Upstream product

• 63389-22-0 5-(4-chloro-phenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 59-88-1 phenylhydrazine hydrochloride 
• 98-86-2 acetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 100-63-0 phenylhydrazine 
• 956-02-5 4'-chlorochalcone 
• 99-91-2 para-chloroacetophenone 
• 100-52-7 benzaldehyde 
• 24721-26-4 4-chlorochalcone 
• 88700-24-7 1-<(methylthio)thiocarbonylmethyl>pyridinium iodide 
• 89144-71-8 N-[(E)-3-(4-Chloro-phenyl)-1-phenyl-prop-2-en-(E)-ylidene]-N'-phenyl-hydrazine 

Downstream Products

• 2515-59-5 C₂₁H₁₇ClN₂⁽¹⁺⁾ 
• 27293-94-3 5-(4-chlorophenyl)-1,3-diphenyl-1H-pyrazole 

Relevant academic research and scientific papers

Spectroscopic studies of aryl substituted 1-phenyl-2-pyrazolines: Steric and electronic substitution effects

A series of aryl substituted 1-phenyl-2-pyrazolines containing electron-donating and electron-withdrawing substituents on different positions of the C3– or C5-aryl groups were synthesized and their steric and electronic effects on ch

Catalytic Synthesis of Chalcones and Pyrazolines Using Nanorod Vanadatesulfuric Acid: An Efficient and Reusable Catalyst

Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and ecologically benign catalyst, was used for the one-pot synthesis of chalcones and 1,3,5-triaryl-2-pyrazolines (TAPs). Chalcones were prepared via the condensation of substituted acetophenones with aryl-aldehydes under solvent-free conditions. Subsequently, the synthesized chalcones were used for the catalytic synthesis of TAPs via two-component condensation with phenyl hydrazine in refluxing ethanol. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate of high purity. Compared to conventional procedures, the present protocol offers several advantages such as simplicity of the procedure, appropriate reaction times, high to excellent yields, easily work-up, recoverability, and reusability of the catalyst, and simple purification of the products.

13C NMR spectroscopy of heterocycles: 1-phenyl-3-aryl/t-butyl-5-arylpyrazoles

A series of chalcones 1-12 were converted to pyrazolines (1Pi-12Pi) by reaction with phenylhydrazine followed by DDQ oxidation to produce the corresponding pyrazoles (1Pz-12Pz). Three 1-phenyl-3-t-butyl-5-arylpyrazoles (13Pz-15Pz) were synthesized using an analogous approach. Molecular modeling studies predicted the 5-aryl group of the pyrazoles for both series to have a torsion angle of 52°-54° whereas the 1-phenyl group was predicted to have 35°-37° torsion angles. The 3-aryl group was predicted to be essentially coplanar (-3°) with the pyrazole system in the first series. 13C NMR data for both series, 1Pz-12Pz and 13Pz-15Pz, were collected in DMSO-d6 at 50°C. A plot of the C4 chemical shifts for 1Pz-12Pz versus Hammet constants for 5-aryl substituents yielded a very good linear correlation (R2=0.96) with a slope of 1.5. The chemical shift data for C4 showed little or no dependence on 3-aryl substituents. The result for 13Pz-15Pz, despite only three points, was consistent with the first series results and yielded a ρ value of 2.0. Distal transmission of substituent effects (5-aryl groups) to C4 of the pyrazole system was reduced by roughly 50-60% of that of the analogous planar isoxazole system, but are not consistent with results for the similarly twisted 4-bromoisoxazoles.

Synthesis and anticancer activity of 1,3,5-triaryl-1H-pyrazole

Previous studies demonstrated that some pyrazole derivatives could be considered as potential anticancer agents. A series of 1,3,5-triaryl-1H-pyrazole derivatives were prepared by the reaction of phenylhydrazin and different chalcones. The previous classi

SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H

Cathepsins have emerged as potential drug targets for melanoma therapy and engrossed attention of researchers for development and evaluation of cysteine cathepsin inhibitors as cancer therapeutics. In this direction, we have designed, synthesized, and ass

Solvent free synthesis of substituted-2-pyrazolines using imidazolium based ionic liquid as a solvent and catalyst: A green route approach

A series of substituted-2-pyrazolines synthesized using imidazolium based ionic liquid, 1,2-[bis-(3'-methyl-imidazolium-hydrogen sulphate)]-ethane as a solvent and catalyst, by reacting chalcones react with phenyl hydrazine. The compounds were characteriz

Nanocasting, Template Synthesis, and Structural Studies on Cesium Salt of Phosphotungstic Acid for the Synthesis of Novel 1,3,5-Triaryl-pyrazoline Derivatives

The elimination of the silica matrix of composites by HF occurred by a two-step reaction deposition of a Cs2.5H0.5PW12O40 (CsHPW) salt nanocrystal. We used 2D hexagonal SBA-15 silica as a template for the nanofabrication of CsHPW nanoparticles. Nanocast CsHPW materials are stable against leaching and colloidization in polar solvents. The catalytic performance of the nanocast CsHPW materials exceeded that of bulk Cs2.5H0.5PW12O40, which is the most active among the acidic HPW salts. A series of novel 1,3,5-triaryl-pyrazoline derivatives were synthesized by the reaction between chalcone and phenylhydrazine in high yield in the presence of CsHPW salt nanocrystals.

A convenient and efficient protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines in acetic acid under ultrasound irradiation

1,3,5-Triaryl-2-pyrazolines were synthesized in acetic acid in high yields within 60-180 min under ultrasound irradiation at room temperature.

Nanocasting, template synthesis, and structural studies on cesium salt of phosphotungstic acid for the synthesis of novel 1,3,5-triaryl-pyrazoline derivatives

The elimination of the silica matrix of composites by HF occurred by a two-step reaction deposition of a Cs2.5H0.5PW 12O40 (CsHPW) salt nanocrystal. We used 2D hexagonal SBA-15 silica as a template for the nanof