959903-74-3

Upstream product

• 201230-82-2 carbon monoxide 
• 89619-03-4 2-(4-methoxyphenyl)allylalcohol 
• 790260-90-1 (R)-(+)-2-(methoxycarbonyl)-2-(4-methoxyphenyl)propionic acid 

Downstream Products

• 235101-15-2 ethyl trans-(S)-(+)-4-(4-methoxyphenyl)-4-methylhexa-2,5-dienoate 
• 235101-23-2 methyl (R)-(-)-4-(4-methoxyphenyl)-4-methylhex-5-enoate 
• 235101-25-4 (R)-(+)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-2-methylpropanol 
• 235101-20-9 1-Methoxy-4-((R)-1-methoxymethoxymethyl-1-methyl-allyl)-benzene 
• 235101-19-6 (R)-(+)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-2-methylpropanal 
• 235101-21-0 (R)-2-(4-methoxyphenyl)-2-methylbut-3-en-1-ol 
• 235101-22-1 (R)-2-(4-Methoxy-phenyl)-2-methyl-but-3-enal 
• 191212-50-7 (R)-1-(3,7-dimethylocta-1,6-dien-3-yl)-4-methoxybenzene 
• 191212-52-9 (R)-(-)-4-(4-methoxyphenyl)-4-methylhex-5-en-1-al 
• 87580-60-7 (E)-3-(4-methoxyphenyl)but-2-enal 
• 751467-94-4 (S)-4-Benzylamino-2-(4-methoxy-phenyl)-2-methyl-butyric acid methyl ester 
• 256389-66-9 (S)-1-Benzyl-5-methoxy-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one 
• 256389-69-2 (S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one 
• 256389-65-8 (S)-5-Methoxy-3-(4-methoxy-phenyl)-3-methyl-dihydro-furan-2-one 

Relevant academic research and scientific papers

Synthesis of quaternary carbon centers via hydroformylation

The application of hydroformylation to the synthesis of quaternary carbon centers is reported. The synthesis of the highly substituted carbon is achieved by applying a catalytic amount of 1. Ligand 1 serves as a catalytic directing group by covalently and reversibly binding to both the substrate and catalyst. The intramolecular nature of the directing group strategy accelerates the hydroformylation reaction such that the reaction is performed at mild temperatures (35-55 °C) and with excellent regioselectivity (b:l > 94:6).

Total synthesis of (-)-sporochnol A, the fish deterrent, from a chiral malonate

From a single chiron, the homochiral benzylic malonic acid ester (R)- (+)-2 available with high enantiomeric excess by enzymatic hydrolysis (PLE acetonic powder), enantiomerically pure (-)-sporochnol A 1 was prepared. This versatile method allows preparation of sporochnol 1, via aldehydes 7 and 15, in good overall yield.

An easy access to (S)-pyrrolidinones and -pyrrolidines from chiral benzylic malonates

From chiral benzylic malonic acid esters (R)-(+)-4, available with high enantiomeric excesses by enzymatic hydrolysis (PLE acetonic powder), enantiomerically enriched pyrrolidinones 1 and pyrrolidines 2 were prepared. This rapid and competitive method was