235101-23-2

Upstream product

• 67-56-1 methanol 
• 235101-15-2 ethyl trans-(S)-(+)-4-(4-methoxyphenyl)-4-methylhexa-2,5-dienoate 
• 790260-90-1 (R)-(+)-2-(methoxycarbonyl)-2-(4-methoxyphenyl)propionic acid 
• 235101-22-1 (R)-2-(4-Methoxy-phenyl)-2-methyl-but-3-enal 
• 235101-21-0 (R)-2-(4-methoxyphenyl)-2-methylbut-3-en-1-ol 
• 235101-19-6 (R)-(+)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-2-methylpropanal 
• 235101-20-9 1-Methoxy-4-((R)-1-methoxymethoxymethyl-1-methyl-allyl)-benzene 
• 959903-74-3 methyl (R)-(+)-3-hydroxy-2-(4-methoxyphenyl)-2-methylpropionate 
• 235101-25-4 (R)-(+)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-2-methylpropanol 
• 235101-18-5 methyl (R)-(+)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-2-methylpropionate 
• 186581-53-3 diazomethane 
• 863092-97-1 4-(4-methoxyphenyl)-4-methyl-hex-5-enoic acid 

Downstream Products

• 191212-52-9 (R)-(-)-4-(4-methoxyphenyl)-4-methylhex-5-en-1-al 
• 191212-50-7 (R)-1-(3,7-dimethylocta-1,6-dien-3-yl)-4-methoxybenzene 

Relevant academic research and scientific papers

A new powerful strategy for the organocatalytic asymmetric construction of a quaternary carbon stereogenic center

(Figure Presented) A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position in high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.

Total synthesis of (-)-sporochnol A, the fish deterrent, from a chiral malonate

From a single chiron, the homochiral benzylic malonic acid ester (R)- (+)-2 available with high enantiomeric excess by enzymatic hydrolysis (PLE acetonic powder), enantiomerically pure (-)-sporochnol A 1 was prepared. This versatile method allows preparation of sporochnol 1, via aldehydes 7 and 15, in good overall yield.