98974-04-0

Usage

Uses

Used in Pharmaceutical Industry:
(4R)-4-Ethyl-2-oxazolidinone is used as a starting material for the synthesis of pharmaceuticals and other bioactive compounds. Its chiral nature allows for the development of enantiomerically pure drugs, which can have improved efficacy and reduced side effects compared to their racemic counterparts.
Used in Organic Synthesis:
(4R)-4-Ethyl-2-oxazolidinone serves as a valuable building block in organic synthesis. Its unique structure and reactivity enable the creation of a wide range of chemical compounds, including complex organic molecules and functional materials.
Used as a Solvent:
Due to its polarity and ability to form hydrogen bonds, (4R)-4-Ethyl-2-oxazolidinone has potential as a solvent for various chemical reactions. Its use as a solvent can facilitate certain types of reactions and improve the yield and selectivity of the products.
Used in Asymmetric Catalysis:
The chiral nature of (4R)-4-Ethyl-2-oxazolidinone makes it a promising candidate for use in asymmetric catalysis. As a chiral catalyst, it can help to control the stereochemistry of chemical reactions, leading to the formation of enantiomerically pure products with potential applications in various industries, including pharmaceuticals and agrochemicals.

InChI:InChI=1/C5H9NO2/c1-2-4-3-8-5(7)6-4/h4H,2-3H2,1H3,(H,6,7)/t4-/m1/s1

Upstream product

• 96-20-8 2-aminobutanol 
• 105-58-8 Diethyl carbonate 
• 1659-31-0 2,2'-dipyridyl carbonate 
• 13997-20-1 4-ethyl-1,3-oxazolidine-2-thione 
• 592-35-8 butyl carbamate 
• 13973-23-4 2--1-butanol 
• 57-13-6 urea 
• 530-62-1 1,1'-carbonyldiimidazole 
• 5856-63-3 (2R)-2-aminobutan-1-ol 
• 124-38-9 carbon dioxide 
• 98-59-9 p-toluenesulfonyl chloride 
• 75-44-5 phosgene 
• 2549-67-9 2-ethylaziridine 
• 201230-82-2 carbon monoxide 

Downstream Products

• 5467-84-5 1,3-diphenethylurea 
• 1466-67-7 1,3-dibenzylurea 
• 100317-12-2 N-benzyl-N'-(1-hydroxymethyl-propyl)-urea 
• 6744-64-5 N,N'-dibenzhydryl-urea 
• 101785-47-1 N-benzhydryl-N'-(1-hydroxymethyl-propyl)-urea 
• 925427-52-7 (R)-4-ethyl-3-styryloxazolidin-2-one 
• 634916-95-3 (4R)-4-ethyl-3-vinyl-oxazolidin-2-one 
• 725257-88-5 (2R,4R)-2-[(4R)-4-ethyl-2-oxo-1,3-oxazolidin-3-yl]-4-phenyl-3,4-dihydro-2H-pyran-6-carboxylic acid methyl ester 
• 130949-42-7 2,2-dimethyl-4-(4,R-ethyl-3-oxazolidinyl-2-one)-6-phenylsulfonyl-2H-benzo[b]pyran 

Relevant academic research and scientific papers

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound useful in the treatment of a neurodegenerative disorder and their combined use as a medicament, in particular for the treatment of neurodegenerative and/or cognitive disorders.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound which compound is useful in the treatment of a psychiatric disorder and their combined use as a medicament, in particular for the treatment of psychiatric and/or cognitive disorders.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Synthesis of cyclic N-nitrourethanes by the simultaneous oxidative desulfurization and nitration of cyclic thiourethanes

The reaction of five- and six-membered cyclic thiourethanes with acetyl nitrate results in a vigorous reaction that generates copious amounts of red-brown nitrogen oxide fumes and produces the corresponding cyclic N-nitrourethanes in high yields (>95%). The overall yield of the cyclic N-nitrourethanes starting from an aminoalcohol using the " thiourethane" route is superior to the conventional route going through the cyclic urethane. Copyright

Synthesis of some 2-Oxazolidinones in mild conditions

One step efficient protocol for the synthesis of 2-oxazolidinones in paste chemical medium is described under microwave activation with 80 % yield.

A novel way to chiral 2-oxazolidinones: selenium-catalyzed cyclocarbonylation of 2-aminoethanols

Selenium-catalyzed cyclocarbonylation of 2-aminoethanols with CO under atmospheric pressure at 30 °C afforded 2-oxazolidinones in excellent yields without any other co-catalyst. The method was then applied to the syntheses of chiral 2-oxazolidinones and no racemization was detected.

Synthesis of 2-oxazolidinones by salen-Co-complexes catalyzed oxidative carbonylation of β-amino alcohols

2-Oxazolidinones are synthesized in high yield by oxidative carbonylation of β-amino alcohols using salen-Co(II)/NaI or salen-Co(III)-I as a catalyst and using CO as the carbonyl source. Studies of functional group compatibility using a series of substituted salen-Co(II) or salen-Co(III)-I complexes demonstrate a broad tolerance of functionality during the carbonylation reaction.

A novel and efficient (NHC)CuI (NHC = N-heterocyclic carbene) catalyst for the oxidative carbonylation of amino compounds

Oxidative carbonylation of amino compounds to prepare corresponding 2-oxazolidinones, ureas, and carbamates selectively in the presence of (NHC)CuI without any additives was firstly achieved in good yields and selectivities.

Efficient synthesis of oxazolidin-2-one via (chitosan-Schiff base)cobalt(II)-catalyzed oxidative carbonylation of 2-aminoalkan-1-ols

The (chitosan-Schiff base)cobalt(II) complex was found to be an efficient catalyst for the oxidative carbonylation (CO/O2) of 2-aminoalkan-1-ols 1 to give oxazolidin-2-ones 2, in the presence of NaI. The effects of promoters, temperature, solvents, and other reaction conditions were investigated in this study.

Pd(Phen)Cl2 stabilized by ionic liquid: an efficient and reusable catalyst for biphasic oxidative cyclocarbonylation of β-aminoalcohols and 2-aminophenol

Biphasic oxidative cyclocarbonylation of β-aminoalcohols and 2-aminophenol to synthesize corresponding 2-oxazolidinones were investigated in the presence of ionic liquid stabilized Pd(phen)Cl2 complex. Catalytic comparison results showed that, 1-butyl-3-methyl-imidazolium iodide salts (BMImI) can serve simultaneously as a specific stabilizer to protect the transition metal complex against deactivation, a promoter to increase the catalytic performance and a reaction medium to recycle the catalyst with unprecedented TOF value.