98991-10-7Relevant academic research and scientific papers
Tuning Rate of the Bergman Cyclization of Benzannelated Enediynes with Ortho Substituents
Alabugin, Igor V.,Manoharan, Mariappan,Kovalenko, Serguei V.
, p. 1119 - 1122 (2002)
matrix presented The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents.
The Synthesis and Ionization of Some Derivatives of 1-Biphenylenol
Hine, Jack,Hahn, Soonkap,Miles, David E.,Ahn, Kyunghye
, p. 5092 - 5096 (2007/10/02)
2,7-Dimethyl-1,8-biphenylenediol has been synthesized from 2-methyl-5-nitrophenol in nine steps. 1,5-Biphenylenediol has been prepared by dimerization of 3-methoxybenzyne, separation of isomers, and demethylation. 8-Methoxy-1-biphenylenol has been made by the partial demethylation of 1,8-dimethoxybiphenylene.Ionization constants (pK1 8.04, pK2 11.47, pK1 8.35, pK2 9.97, and pK 9.15, respectively) have been determined for these compounds and for 1,8-biphenylenediol (pK1 8.01, pK2 11.00) and 1- biphenylenol (pK 8.64) by ultraviolet spectrophotomeric measurements in aqueous solution.
