Dioxygenase catalyzed biotransformation of aromatic compounds to the corresponding cis-dihydrodiols

February 05, 2024

• Title:

  Dioxygenase catalyzed biotransformation of aromatic compounds to the corresponding cis-dihydrodiols

• Image Source:

  Asymmetric dihydroxylation of cinnamonitrile to trans-3-[(5S,6R)-5,6- dihydroxycyclohexa-1,3-dienyl]-acrylonitrile using chlorobenzene dioxygenase in Escherichia coli (pTEZ30)

• Mark:

  Figure 1

• Associated context:

  Oxidation of aromatic compounds to cis-dihydrodiols is  catalyzed by multicomponent bacterial dioxygenases  (Figure 1).^[1,2] These reactions are of special interest,  since cis-dihydrodiols are valuable buildingblocks for  the stereoselective synthesis of molecules containing multiple chiral centers.