Combined Pd-, Ru-, and Ni-catalyzed cross-coupling reactions to triaryl fluorenones

February 29, 2024

• Title:       

  Combined Pd-, Ru-, and Ni-catalyzed cross-coupling reactions to triaryl fluorenones 

• Image Source:

  Chemoselective Ruthenium-Catalyzed C-O Bond Activation: Orthogonality of Nickel-and Palladium-Catalyzed Reactions for the Synthesis of Polyaryl Fluorenones

• Mark:

  Scheme 6

• Associated context:

  To further pursue the orthogonality concept, chloro derivatives 1f and 1g, prepared by the DoM/Suzuki-Miyaura  coupling/DreM strategy, were subjected to Suzuki–Miyaura  coupling under conditions suitable for aryl chlorides33 to  give the 8-methoxy and 8-O-carbamates 9a and 9b, respectively (Scheme 6). Compound 9a underwent Ru-catalyzed  coupling with Ph-Bneop (6a) and 4-methoxy-phenyl-Bneop (6b) to afford the first cases of 1,4,8-triarylfluorenones 12a  and 12b, respectively.