Rapid Analysis of Plasma Paraquat Using Sodium Dithionite As a Predictor of Outcome in Acute Paraquat Poisoning
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Add time:07/26/2019 Source:sciencedirect.com
BackgroundParaquat poisoning can be lethal, and aggressive treatments might have little or no effect on severely poisoned patients. Accordingly, a convenient prognostic test is necessary to guide therapy for acute paraquat poisoning. Sodium dithionite reduces paraquat to a blue radical form in alkaline plasma with a paraquat detection sensitivity of 2.0 mg/L, which is a 100% lethal concentration at 10 to 12 hours postingestion. The prognostic utility of this simple reaction was examined prospectively.
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