Copper(I)-catalyzed benzylic C(sp3)–H geminal difunctionalization: Successive oxidative intramolecular amidation and hydroxylation

Add time:07/18/2019    Source:sciencedirect.com

A selective copper(I)-catalyzed benzylic C(sp3)–H geminal difunctionalization reaction of a benzylic-type sp3 carbon was developed. This novel strategy allowed simultaneous introduction of amide and hydroxyl group in a highly selective and efficient way via successive oxidative intramolecular amidation and hydroxylation. This method was also applied to the synthesis of 3-hydroxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinoxalinones from readily available 3-methyl-N-substituted quinoxaline-2-carboxamides in moderate to good yields. The five-membered cyclic hemiaminal moiety of the pyrrolo[3,4-b]quinoxalinones can serve as an intermediates for subsequent transformations into other useful functional groups.

We also recommend Trading Suppliers and Manufacturers of 2-Butyl-3-phenylquinoxaline 1-oxide (cas 18992-52-4). Pls Click Website Link as below: cas 18992-52-4 suppliers

Prev:Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid (cas 18992-11-5) in human melanocytic cells
Next:Mutagenicity of aminocarbazoles and nitrocarbazoles)