The herbal preparation abana (cas 105863-96-5) protects against radiation-induced micronuclei in mouse bone marrow

Add time:07/19/2019    Source:sciencedirect.com

The induction of micronuclei was studied in mouse bone marrow treated or not with 5, 10 and 20 mg/kg b.wt. of abana (cas 105863-96-5) (a herbal preparation) before exposure to 0–3 Gy of γ-radiation. Whole-body irradiation of mice resulted in a dose-dependent increase in the frequency of micronuclei. Treatment of mice with various doses of abana before exposure to different doses of γ-rays resulted in a significant reduction of the micronucleus frequency at all exposure doses. The highest decline in the frequencies of micronuclei was observed after administration of 20 mg/kg abana, where the frequency of micronuclei was approximately 4-fold less than that of the concurrent control. The PCE/NCE ratio was significantly higher in the drug-treated group compared to DDW+irradiated control and it was almost restored to normal level after administration of 20 mg/kg abana. Our results demonstrate that abana protects mice against radiation-induced micronucleus formation and radiation-induced decline in cell proliferation.

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