Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis

Add time:07/19/2019    Source:sciencedirect.com

Synthesis of dimeric nucleoside building with a N-cyanoguanidine linkage was performed by reaction of 3′-amino-3′-deoxythymidine with S,S-dimethyl-N-cyanodithioimidocarbonate followed by reaction of the obtained isothiourea with 5′-amino-2′,5′-dideoxynucleosides. These dimers were protected in the 5′-position and converted into their phosphoramidites. Oligonucleotides were synthesized using these building blocks.

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