Highly enantioselective Friedel–Crafts reaction of indoles with N-sulfonyl aldimines catalyzed by heteroarylidene malonate-type bis(oxazoline) copper(II) complexes

Add time:07/19/2019    Source:sciencedirect.com

The enantioselective Friedel–Crafts addition of indoles to N-sulfonyl aldimines was studied using a heteroarylidene malonate-type bis(oxazoline) as a chiral ligand. High to excellent enantioselectivities (up to >99% ee) were achieved using the complex of copper(II)–L1b with a benzyl group. The effects of ligand structure, solvent, temperature and substrate on the reaction were also investigated.

We also recommend Trading Suppliers and Manufacturers of BIS-(4-BROMOPHENYL) MALONATE (cas 116210-64-1). Pls Click Website Link as below: cas 116210-64-1 suppliers

Prev:Palladium-catalyzed decarboxylative C3-acylation of benzofurans and benzothiophenes with α-oxocarboxylic acids via direct sp2 C–H bond activation
Next:The synthesis of phosphine oxide-linked bis(oxazoline) ligands and their application in asymmetric allylic alkylation)