Formation of Nε-Dnp Lysine during deprotection of Nε-Fmoc lysine in Nim-DNP-histidine-containing peptides

Add time:07/19/2019    Source:sciencedirect.com

The 2,4-dinitrophenyl group used for histidine side chain protection is not stable during aminolytic removal of Fmoc protecting groups. In the presence

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