Cell growth inhibition by 3-deoxysappanchalcone (cas 112408-67-0) is mediated by directly targeting the TOPK signaling pathway in colon cancer

Add time:07/19/2019    Source:sciencedirect.com

BackgroundColorectal cancer is one of the most common causes of cancer death worldwide. Unfortunately, chemotherapies are limited due to many complications and development of resistance and recurrence. The T-lymphokine-activated killer cell-originated protein kinase (TOPK) is highly expressed and activated in colon cancer, and plays an important role in inflammation, proliferation, and survival of cancer cells. Therefore, suppressing TOPK activity and its downstream signaling cascades is considered to be a rational therapeutic/preventive strategy against colon cancers.

We also recommend Trading Suppliers and Manufacturers of 3-deoxysappanchalcone (cas 112408-67-0). Pls Click Website Link as below: cas 112408-67-0 suppliers

Prev:Combustion characteristics of fatty acid methyl esters derived from recycled cooking oil
Next:The anti-inflammatory effect of 3-deoxysappanchalcone (cas 112408-67-0) is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages)