Heterogeneous copper-catalyzed decarboxylative cyclization of 2-benzoylpyridines with α-amino acids leading to imidazo[1,5-a]pyridines

Add time:07/22/2019    Source:sciencedirect.com

The heterogeneous decarboxylative cyclization reaction between 2-benzoylpyridines and α-amino acids was achieved in toluene at 120 °C in the presence of 15 mol% of l-proline-functionalized MCM-41-supported copper(II) complex [l-Proline-MCM-41-Cu(OTf)2] and iodine with di-tert-butyl peroxide (DTBP) as oxidant, yielding a variety of 1,3-disubstituted imidazo[1,5-a]pyridines in good to excellent yields. The new supported copper catalyst can be prepared from commercially available and inexpensive reagents, and recovered from the reaction mixture by a simple filtration and recycled up to eight times with almost consistent activity.

We also recommend Trading Suppliers and Manufacturers of 5-CHLORO-2-(CHLOROMETHYL)PYRIDINE (cas 10177-24-9). Pls Click Website Link as below: cas 10177-24-9 suppliers

Prev:Direct and cobalt(I) salen-catalyzed reduction of 2,6-bis(chloromethyl)pyridine at carbon cathodes in acetonitrile
Next:Discovery of pyridine-based agrochemicals by using Intermediate Derivatization Methods)