Pyrrolidine carbamate nucleic acids: Synthesis and DNA binding studies

Add time:07/21/2019    Source:sciencedirect.com

An efficient solid phase synthesis of pyrrolidine carbamate nucleic acids is reported. The protected (2S, 4S)-4-aminopyrrolidine-2-methanol with nucleobases thymine and cytosine attached to the ring nitrogen through an acetyl linker can be activated as nitrophenyl carbonates for the synthesis of dimer, trimer and oligomers.

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