Evaluation of antihypertensive effects of S.9-390 (2-(o-chlorobenzyl) imidazoline hydrochloride)
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Add time:07/20/2019 Source:sciencedirect.com
The evaluation of a new, orally active antihypertensive agent, S.9-390 (2-(o-chlorobenzyl) imidazoline hydrochloride), has been presented. In human beings, the drug was found to have effects suggesting both central antihypertensive and ganglionic blocking action, but no characteristic adrenolytic properties. Although toxicity was minimal, the development of drug resistance prohibits its wide clinical use in hypertensive disease. It presents, however, many desirable features of an antihypertensive agent, so that further clinical studies in this field are warranted.
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