Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities

Add time:07/20/2019    Source:sciencedirect.com

New microtubule depolymerizing agents with potent cytotoxic activities have been prepared with a 5-cyano or 5-oximino group attached to a pyrrole core. The utilization of ortho activation of a bromopyrrole ester to facilitate successful Suzuki-Miyaura cross-coupling reactions was a key aspect of the synthetic methodology. This strategy allows for control of regiochemistry with the attachment of four completely different groups at the 2, 3, 4 and 5 positions of the pyrrole scaffold. Biological evaluations and molecular modeling studies are reported for these examples.

We also recommend Trading Suppliers and Manufacturers of 1H-INDOLE-3-CARBOXYLIC ACID,6-BROMO-ETHYL ESTER (cas 103858-55-5). Pls Click Website Link as below: cas 103858-55-5 suppliers

Prev:Radiolabeling of protected tryptophan with [18F]fluoromethyl tosylate: Formation of [18F]fluoromethyl ester of tryptophan instead of 1-N-[18F]fluoromethyl tryptophan methylester.
Next:Are carboxylic esters really refractory to DAST? On the fluorination of α-hydroxyesters with DAST)