Diverse in vitro and in vivo anti-inflammatory effects of trichlorido-gold(III) complexes with N6-Benzyladenine (cas 1214-39-7) derivatives
-
Add time:07/28/2019 Source:sciencedirect.com
A series of gold(III) complexes involving differently substituted derivatives of a plant hormone N6-benzyladenine (HL1–5) is reported. The complexes have the general formula [Au(HL1–5)Cl3]∙nH2O (n = 0 for 1, 3–5; and n = 1 for 2), where N6-(2-fluorobenzyl)adenine (HL1), N6-(2-chlorobenzyl)adenine (HL2), N6-(3-chlorobenzyl)adenine (HL3), N6-(4-chlorobenzyl)adenine (HL4) and N6-(4-methylbenzyl)adenine (HL5) represent the N9-coordinated ligands. The results of thorough characterization (elemental and thermal analyses, FT-IR, Raman and NMR spectroscopies, ESI + mass spectrometry, conductivity measurements, DFT calculations) showed that the presented complexes 1–5 involve a central gold(III) atom coordinated in a square-planar geometry by the N9 atom of the purine moiety of HL1–5 and by three chlorido ligands. The complexes (1–5) were studied in vitro for cytotoxicity and anti-inflammatory activity on LPS-activated macrophages (THP-1 cell line), and in vivo for anti-inflammatory effects (1, 2, 5) using the carrageenan-induced hind paw oedema model on rats. Surprisingly, the results on the in vitro level revealed that the complexes show negligible cytotoxicity and anti-inflammatory activity, however, the activity on the in vivo level was found to be significant, fully comparable with the utilized drug Indomethacin, or even better as compared to a gold-containing metallodrug Auranofin.
We also recommend Trading Suppliers and Manufacturers of Benzyladenine (cas 1214-39-7). Pls Click Website Link as below: cas 1214-39-7 suppliers
Prev:Nitrogen fertilization and chemical thinning with 6-Benzyladenine (cas 1214-39-7) affect fruit set and quality of golden delicious apples
Next:The metabolism of Benzyladenine (cas 1214-39-7) by excised organs of Phaseolus vulgaris) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- The metabolism of Benzyladenine (cas 1214-39-7) by excised organs of Phaseolus vulgaris07/29/2019
- Nitrogen fertilization and chemical thinning with 6-Benzyladenine (cas 1214-39-7) affect fruit set and quality of golden delicious apples07/27/2019
- Optimising crop load and fruit quality of ‘Packham’s Triumph’ pear with ammonium thiosulfate, ethephon and 6-Benzyladenine (cas 1214-39-7)07/26/2019
- Increase in final fruit size of tangor (Citrus reticulata × C. sinensis) cv W. Murcott by application of Benzyladenine (cas 1214-39-7) to flowers07/25/2019
- Investigation on the effect of Benzyladenine (cas 1214-39-7) on the germination, radicle growth and meristematic cells of Nigella sativa L. and Allium cepa L.07/24/2019
- Cytokinin activity of N6-Benzyladenine (cas 1214-39-7) derivatives assayed by interaction with the receptors in planta, in vitro, and in silico07/23/2019
- The production of alkaloids in Annona cacans seedlings is affected by the application of GA4+7 + 6-Benzyladenine (cas 1214-39-7)07/22/2019
- Thermodynamic models for determination of solid–liquid equilibrium of the 6-Benzyladenine (cas 1214-39-7) in pure and binary organic solvents07/20/2019
- Response of Fennel (Foeniculum vulgare, Mill) plants to foliar application of moringa leaf extract and Benzyladenine (cas 1214-39-7) (BA)07/21/2019