Synthesis and characterization of novel trans-3-benzyl/(diphenyl)methyl/naphthyl seleno substituted monocyclic β-lactams: X-ray structure of trans-1-(4′-methoxyphenyl)-3-(diphenyl)methylseleno-4-(4′-methoxyphenyl)azetidin-2-one

Add time:07/11/2019    Source:sciencedirect.com

Several novel trans-3-benzyl/(diphenyl)methyl/naphthylseleno substituted monocyclic β-lactams (5–7) have been synthesized in high yields. The reaction scheme inolves [2 + 2] cycloaddition (Staudinger) reaction between suitably substituted imines 4(a–h) and ketenes (B) accessed from 2-benzyl/(diphenyl)methyl/naphthylselenoethanoic acids (1–3) using POCl3 and triethylamine in refluxing toluene. Characterization of these newly synthesized seleno substituted β-lactams has been performed by various spectroscopic techniques viz. NMR (1H, 13C and 77Se), FTIR, mass spectrometry and elemental analysis. The molecular structure of trans-1-(4′-methoxyphenyl)-3-(diphenyl)methylseleno-4-(4′-methoxyphenyl)azetidin-2-one (6b) has also been established with the help of single crystal X-ray analysis.

We also recommend Trading Suppliers and Manufacturers of 1-BENZYL-3-(4-METHOXYPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE (cas 588674-26-4). Pls Click Website Link as below: cas 588674-26-4 suppliers

Prev:Synthesis of conformationally restricted 1,2,3-triazole-substituted ethyl β- and γ-aminocyclopentanecarboxylate stereoisomers. Multifunctionalized alicyclic amino esters
Next:A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects)