Carbonylative formation of N-acetyl-2,6-difluorobenzamide through N–H bond activation of 2,6-difluorobenzamide with Ni(II) complex supported with phosphine ligands

Add time:07/21/2019    Source:sciencedirect.com

Fluorinated imide, N-acetyl-2,6-difluorobenzamide (C6H3F2-2,6)C(O)NHC(O)Me 2, could be obtained through one-pot reaction of NiMe2(PMe3)3 with 2,6-difluorobenzamide (C6H3F2-2,6)C(O)NH2 1 in CO atmosphere. A postulated reaction mechanism via N–H bond cleavage and carbonylative reductive elimination on nickel center was partly experimentally confirmed. An important intermediate (C6H3F2-2,6)C(O)HNNiMe(PMe3)2 3 was isolated and structurally characterized.

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